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Ir Genes

Past, Present, and Future

  • Book
  • © 1983

Overview

Editors:
  1. Carl W. Pierce

    1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, USA

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  2. Susan E. Cullen

    1. Department of Microbiology and Immunology, Washington University, St. Louis, USA

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  3. Judith A. Kapp

    1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, USA

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  4. Benjamin D. Schwartz

    1. Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, USA

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  5. Donald C. Shreffler

    1. Department of Genetics, Washington University School of Medicine, St. Louis, USA

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Part of the book series: Experimental Biology and Medicine (EBAM, volume 4)

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About this book

The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

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Table of contents (86 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Genetic Organization of I-Region Genes

    1. Front Matter

      Pages 1-1
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    2. Ia Genes, Gene Products, and Determinants

      • Chella S. David, William P. Lafuse
      Pages 3-12

    3. Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A-Encoded Molecule

      • Colleen E. Hayes, Robert M. Whitcomb, David P. Krum, Karen K. Klyczek, Debra A. Hullett
      Pages 13-17

    4. Definition of New Ia+ T Cell Subsets

      • Mauro S. Sandrin, Jenni S. Craig, Ian F. C. McKenzie
      Pages 19-22

    5. Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C-H-2 bm12

      • William Walsh, Frances Pappas, Regina Skelly, Ted Hansen
      Pages 23-28

    6. Induction of Autoreactive T Cells by Stimulation Across the I-J Subregion

      • Mark C. Horowitz, Donal B. Murphy
      Pages 29-38

    7. Enhancement of Murine T Cell I-J Expression by Limited Proteolysis

      • Karen Klyczek, Debra Hullett, Colleen Hayes
      Pages 39-43

    8. Isolation and Analysis of Subpopulations of I-Ab Molecules with Monoclonal Antibodies

      • William Lafuse, Michel Pierres, Chella S. David
      Pages 45-49

    9. Partial Characterization of 8 Anti-I-J and 3 Anti-Ia Monoclonal Reagents

      • V. Hauptfeld, M. Hauptfeld, M. Nahm, J. Trial, J. Kapp, D. Shreffler
      Pages 51-55

    10. Interspecies Cross Reactivity of Monoclonal Anti-I-E Antibodies Specific for Polymorphic Ia Determinants

      • J. K. Lunney, B. A. Osborne, C. Devaux, M. Pierres, D. H. Sachs
      Pages 57-61

    11. Structural Characterization of I-Ab Subsets Using Monoclonal Antibodies

      • Sujay K. Singh, William P. Lafuse, David J. McKean, Chella S. David
      Pages 63-67

    12. Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP)

      • John J. Monaco, Grace Ku, Hugh O. McDevitt
      Pages 69-73

    13. Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes

      • Michelle Letarte, Jun Okamura, Jane B. L. Addis, Roland Tisch, Erwin W. Gelfand
      Pages 75-79

    14. Use of Monoclonal Antibodies for Studies of Anti-Ia Receptor Idiotypes

      • Suzanne L. Epstein, David H. Sachs
      Pages 81-90

    15. A Recombinatorial Event Separating the Immune Response Genes for LDH-B and MOPC-173: Implications for a New Model of I Region Gene Organization

      • David H. Gutmann, Paul M. Allen, John E. Niederhuber
      Pages 91-95

    16. Expression of Ia Antigens and Ir Gene Function During Differentiation of Bone Marrow Derived Macrophage

      • L. B. Schook, D. H. Gutmann, L. E. Marlin, J. E. Niederhuber
      Pages 97-101

    17. The IR-THY-1 Genes: Possible Mechanism of Their Effect

      • J. S. Reichner, M. B. Zaleski
      Pages 103-107

    18. Complementing IR-Genes Located in the I-A Subregion and between the S and D Regions are Required for the Response to TNP-Ficoll

      • Linda M. Hillstrom, John E. Niederhuber
      Pages 109-113

  3. Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products

    1. Front Matter

      Pages 115-115
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Editors and Affiliations

  • Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, USA

    Carl W. Pierce, Judith A. Kapp

  • Department of Microbiology and Immunology, Washington University, St. Louis, USA

    Susan E. Cullen

  • Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, USA

    Benjamin D. Schwartz

  • Department of Genetics, Washington University School of Medicine, St. Louis, USA

    Donald C. Shreffler

Bibliographic Information

  • Book Title: Ir Genes

  • Book Subtitle: Past, Present, and Future

  • Editors: Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Benjamin D. Schwartz, Donald C. Shreffler

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-5633-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The HUMANA Press Inc. 1983

  • Hardcover ISBN: 978-0-89603-050-3Published: 21 March 1983

  • Softcover ISBN: 978-1-4612-5635-9Published: 04 November 2011

  • eBook ISBN: 978-1-4612-5633-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXVI, 622

  • Topics: Immunology

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