Overview
- Editors:
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Ronald T. Borchardt
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Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, USA
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Cyrus R. Creveling
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NIADDK, National Institutes of Health, Bethesda, USA
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Per Magne Ueland
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Department of Pharmacology, University of Bergen, Bergen, Norway
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Table of contents (37 chapters)
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Protein and Phospholipid Methylations
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- Woon Ki Paik, Sangduk Kim, Hyang Woo Lee
Pages 15-23
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- Melvin L. Billingsley, Randall L. Kincaid, Marina E. Wolf, Robert H. Roth, Walter Lovenberg, Carey D. Balaban et al.
Pages 25-41
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- Gerald L. Hazelbauer, John Bollinger, Chankyu Park, Dawn Nowlin, Maqsudul Alam
Pages 43-53
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- Jon Bremer, Kaare Norum, Pål Bjørnstad
Pages 55-66
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- Fusao Hirata, Masakazu Hatanaka, Yuji Wano, Keiichi Matsuda
Pages 67-74
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- Dennis E. Vance, Neale Ridgway
Pages 75-88
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- I. Varela, M. Pajares, I. Merida, M. Villalba, C. Cabrero, P. Ortiz et al.
Pages 89-99
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- M. Lakher, R. J. Wurtman, J. Blusztajn, P. Holbrook, J-C. Maire, C. Mauron et al.
Pages 101-110
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Nucleic Acid Methylations
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Front Matter
Pages 111-111
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- Walter Doerfler, Klaus-Dieter Langner, Dagmar Knebel, Ulrike Weyer
Pages 139-150
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- Lionel A. Poirier, Mary J. Wilson, Narayan Shivapurkar
Pages 151-161
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- F. Rottman, P. Narayan, R. Goodwin, S. Camper, Y. Yao, S. Horowitz et al.
Pages 189-200
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Regulation of S-Adenosylmethionine, S-Adenosylhomocysteine, and Methylthioadenosine Metabolism
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Front Matter
Pages 201-201
About this book
This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).
Editors and Affiliations
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Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, USA
Ronald T. Borchardt
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NIADDK, National Institutes of Health, Bethesda, USA
Cyrus R. Creveling
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Department of Pharmacology, University of Bergen, Bergen, Norway
Per Magne Ueland
