Enzymology of Protein Methylation: Recent Development

  • Woon Ki Paik
  • Sangduk Kim
  • Hyang Woo Lee
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 12)

Abstract

The presence of ε-N-methyllysine was first observed in Salmonella typhimurium in 1959. Since this discovery the ubiquitous occurrence of protein methylation in nature has been well established (Paik & Kim, 1980). It involves N-methylation of lysine, arginine, histidine, alanine, proline, and glutamine, O-methylation of glutamic and aspartic acid, and S-methylation of methionine and cysteine (Paik & Kim, 1985). As shown in Table I, methylated amino acids occur in highly specialized proteins such as histones, flagella protein, myosin, actin, ribosomal proteins, opsin, EFlα(Tu), HnRNP protein, HMG-1 and HMG-2 protein, fungal and plant cytochrome c, myelin basic protein, porcine heart citrate synthase, heat-shock proteins, nucleolar protein, ferredoxin, wheat α-amylase, and calmodulin.

Keywords

Proline Lysine Arginine Glutamine Methionine 

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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Woon Ki Paik
    • 1
  • Sangduk Kim
    • 1
  • Hyang Woo Lee
    • 1
  1. 1.Fels Research InstituteTemple University School of MedicinePhiladelphiaUSA

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