Enzymology of Protein Methylation: Recent Development

  • Woon Ki Paik
  • Sangduk Kim
  • Hyang Woo Lee
Part of the Experimental Biology and Medicine book series (EBAM, volume 12)


The presence of ε-N-methyllysine was first observed in Salmonella typhimurium in 1959. Since this discovery the ubiquitous occurrence of protein methylation in nature has been well established (Paik & Kim, 1980). It involves N-methylation of lysine, arginine, histidine, alanine, proline, and glutamine, O-methylation of glutamic and aspartic acid, and S-methylation of methionine and cysteine (Paik & Kim, 1985). As shown in Table I, methylated amino acids occur in highly specialized proteins such as histones, flagella protein, myosin, actin, ribosomal proteins, opsin, EFlα(Tu), HnRNP protein, HMG-1 and HMG-2 protein, fungal and plant cytochrome c, myelin basic protein, porcine heart citrate synthase, heat-shock proteins, nucleolar protein, ferredoxin, wheat α-amylase, and calmodulin.


Myelin Basic Protein Wheat Germ Neurospora Crassa Nucleolar Protein Euglena Gracilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Woon Ki Paik
    • 1
  • Sangduk Kim
    • 1
  • Hyang Woo Lee
    • 1
  1. 1.Fels Research InstituteTemple University School of MedicinePhiladelphiaUSA

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