Overview
- Editors:
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Jonathan J. Li
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Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, USA
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Sara Antonia Li
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Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, USA
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Janet R. Daling
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Division of Public Health Sciences Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
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About this book
Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.
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Article
Open access
25 November 2014
Table of contents (59 papers)
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Organ Site: Prostate/Ovary
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- Gerald R. Cunha, Simon W. Hayward, Thea Tlsty, Gary D. Grossfeld
Pages 320-332
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- Grant Buchanan, Wayne D. Tilley
Pages 333-341
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Osteoporosis and Estrogen
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Front Matter
Pages 343-343
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Cardiovascular Disease and Estrogen/Progestins
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Front Matter
Pages 363-363
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Viewpoint
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Front Matter
Pages 385-385
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Epilogue
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Front Matter
Pages 401-401
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- Jonathan J. Li, Sara Antonia Li
Pages 403-405
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Communications
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Front Matter
Pages 407-407
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- C. Magnusson, I. R. Persson, E. Weiderpass, N. Correia
Pages 409-412
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- H. Jernström, O. Johannsson, Å. Borg, H. Olsson
Pages 413-417
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- Seema A. Khan, Scott Stickles
Pages 418-423
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- Kazuhiro Ikeda, Satoshi Inoue, Akira Orimo, Hisahiko Hiroi, Fujiko Tsuchiya, ItsuoGorai et al.
Pages 424-428
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- Bernd Stein, May Sutherland, Stephanie Lipps, Joseph Lewcock, Helen Brady, Lynn Ransone
Pages 429-434
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Communications
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Front Matter
Pages 435-435