Overview
- The first comprehensive handbook on immunosenescence
- First to treat in one volume all the aspects of immunosenescence
- Bridging bench research and clinical applications
- Written by internationally recognised people in the field of immunosenescence
- Useful for anti-aging research and clinic
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About this book
“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”
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Keywords
Table of contents (77 chapters)
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Methods and Models for Studying Immunosenescence
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Cellular Immunosenescene - T Cells
Reviews
Editors and Affiliations
Bibliographic Information
Book Title: Handbook on Immunosenescence
Book Subtitle: basic understanding and clinical applications
Editors: Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec
DOI: https://doi.org/10.1007/978-1-4020-9063-9
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2009
Hardcover ISBN: 978-1-4020-9062-2Published: 25 February 2009
Softcover ISBN: 978-94-017-7721-6Published: 23 August 2016
eBook ISBN: 978-1-4020-9063-9Published: 27 February 2009
Edition Number: 1
Number of Pages: XXXI, 1693
Topics: Biomedicine general, Immunology, Geriatrics/Gerontology