Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations

  • A. A. Romanyukha
  • S. G. Rudnev
  • T. A. Sannikova
  • A. I. Yashin


Mathematical modeling of immunosenescence is the new area of research emerging at the interface of the immunology, gerontology, and mathematics. In this paper we outline basic variables important for modeling aging immunity. We discuss the role of evolution in shaping pattern of aging in the immune system of modern humans. We investigate mathematical models of postnatal changes in the population of peripheral T-cells, effects of the antigenic load during development on the body growth, and contribution of immunosenescence to the old age increase in the risk of death from respiratory infections.

Antigenic load aging immunity mortality from infections body growth population of T-cells 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • A. A. Romanyukha
    • 1
  • S. G. Rudnev
    • 1
  • T. A. Sannikova
    • 1
  • A. I. Yashin
    • 2
  1. 1.Institute of Numerical MathematicsRussian Academy of SciencesMoscowRussia
  2. 2.Center for Population Health and AgingDuke UniversityDurhamUSA

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