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Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

  • Enrico Lugli
  • Leonarda Troiano
  • Marcello Pinti
  • Milena Nasi
  • Erika Roat
  • Roberta Ferraresi
  • Linda Bertoncelli
  • Lara Gibellini
  • Elisa Nemes
  • Andrea Cossarizza

Abstract

Several cell subsets participate to the immune response, and their close interplay is fundamental for the successful elimination of harmful pathogens. In addition, a tight regulation of the immune response has to occur in order to avoid excessive inflammation and potential autoreactivity towards self components. In the last years, the discovery and the characterization of new lymphocytes subsets, including regulatory T (Treg)-cells and Natural Killer T (NKT)-cells allowed a better understanding of how an effector immune response is induced and therefore down-modulated. During the ageing of the immune system, a process termed immunosenescence, these subsets undergo a profound remodelling, both in phenotype and function. In this chapter, we will describe the essential features of lymphocyte populations in centenarians and the differences that occur with unsuccessfully aged people.

Keywords

Treg Cell Curr Opin Immunol Natural Killer Cell Number Thymic Activity Polychromatic Flow Cytometry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Enrico Lugli
    • 1
  • Leonarda Troiano
    • 1
  • Marcello Pinti
    • 1
  • Milena Nasi
    • 1
  • Erika Roat
    • 1
  • Roberta Ferraresi
    • 1
  • Linda Bertoncelli
    • 1
  • Lara Gibellini
    • 1
  • Elisa Nemes
    • 1
  • Andrea Cossarizza
    • 1
  1. 1.Chair of Immunology, Department of Biomedical SciencesUniversity of Modena and Reggio EmiliaModenaItaly

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