© 2006

Malaria: Genetic and Evolutionary Aspects


Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Krishna R. Dronamraju
    Pages 1-12
  3. Krishna R. Dronamraju
    Pages 13-24
  4. Rajeev K. Mehlotra, Peter A. Zimmerman
    Pages 81-124
  5. Stephen M. Rich, Francisco J. Ayala
    Pages 125-146
  6. V.P. Sharma
    Pages 147-167
  7. J. B. S. Haldane
    Pages 169-174
  8. J. B. S. Haldane
    Pages 175-187
  9. Back Matter
    Pages 189-190

About this book


This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.


Malaria evolution infection infectious infectious disease

Authors and affiliations

  1. 1.Foundation for Genetic ResearchHoustonUSA
  2. 2.Department of Genetics, Biology and BiochemistryUniversity of Torino Medical SchoolTorinoItaly

Bibliographic information

  • Book Title Malaria: Genetic and Evolutionary Aspects
  • Editors Krishna R. Dronamraju
    Paolo Arese
  • Series Title Emerging Infectious Diseases of the 21st Century
  • DOI
  • Copyright Information Springer Science+Business Media, Inc. 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-0-387-28294-7
  • Softcover ISBN 978-1-4419-2102-4
  • eBook ISBN 978-0-387-28295-4
  • Edition Number 1
  • Number of Pages XI, 190
  • Number of Illustrations 26 b/w illustrations, 0 illustrations in colour
  • Topics Science, Humanities and Social Sciences, multidisciplinary
  • Buy this book on publisher's site


From the reviews:

"Malaria focuses on genetic and evolutionary insights into a paradise blamed for the death of a child every 30 s worldwide. … Malaria: Genetic and Evolutionary Aspects will benefit a broad range of medical, scientific, and public health professionals. Besides strengthening our understanding of the evolutionary origins of malaria, the text opens new perspectives into infectious diseases." (Richard A. Stein, American Journal of Physical Anthropology, Vol. 133, 2007)