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Arterial Remodeling: A Critical Factor in Restenosis

  • Book
  • © 1997

Overview

Editors:
  1. Antoine Lafont

    1. Necker University, Paris, France

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    You can also search for this editor in PubMed   Google Scholar

  2. Eric J. Topol

    1. Cleveland Clinic Foundation, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 198)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xxix
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  3. Restenosis and remodeling: the facts

    1. Front Matter

      Pages 49-49
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    2. Experimental Evidence of Remodeling after Angioplasty

      • A. Lafont, E. Durand, S. Drechsel, K. Bougrini, M. Desnos, C. Guérot
      Pages 51-68

    3. Remodeling: Accelerator or Decelerator of Luminal Narrowing in Human Atherosclerotic Arteries

      • Gerard Pasterkamp, Berend Hillen, Cornelius Borst
      Pages 69-80

    4. Histologic Basis of Vessel Remodeling after Various Interventional Procedures: A Comparison of Acute (Cracks, Breaks, Tears, Stretching) and Chronic (Tissue Proliferation, Recoil) Changes

      • Bruce F. Waller, Charles M. Orr, James Van Tassel, Thomas Peters, Edward Fry, James Hermiller
      Pages 81-110

    5. Serial Intravascular Ultrasound Evidence for Arterial Remodeling as a Mechanism of Restenosis Following Interventional Coronary Procedures

      • Gary S. Mintz, Jeffrey J. Popma, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Martin B. Leon
      Pages 111-126

    6. Coronary Blood Flow During Interventional Procedures: Implications for Vascular Remodeling

      • Morton J. Kern
      Pages 127-158

  4. Restenosis and remodeling: the targets revisited

    1. Front Matter

      Pages 159-159
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    2. Restenosis and Remodeling: Is the Adventitia Involved?

      • Jean Grégoire, Michael E. Staab, David R. Holmes Jr., Robert S. Schwartz
      Pages 161-180

    3. Post-Angioplasty Smooth Muscle Cell Apoptosis

      • Gerhard Bauriedel, Sven Schluckebier, Randolph Hutter, Ulrich Welsch, Berndt Lüderitz
      Pages 181-198

    4. Intimal Hyperplasia is the Wrong Target: Restenosis as a Failure of Remodeling

      • Randolph L. Geary, Stephen M. Schwartz
      Pages 199-230

    5. Endothelial Dysfunction after Angioplasty: A Pathway for Remodelling?

      • Thomas F. Lüscher, Georg Noll, Chantal M. Boulanger
      Pages 231-252

  5. Molecular aspects of remodeling

    1. Front Matter

      Pages 253-253
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    2. Vascular Remodeling and Lesion Formation in Restenosis: Implications for Nitric Oxide-Based Therapeutics

      • Gary H. Gibbons
      Pages 255-276

    3. Oxidative Stress and Vascular Remodeling

      • Bradford C. Berk
      Pages 277-304

    4. Matrix Metalloproteinases in Injured Artery

      • Eric Allaire, Peter Libby, Alexander W. Clowes
      Pages 305-338
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Keywords

About this book

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem.
There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion.
The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Editors and Affiliations

  • Necker University, Paris, France

    Antoine Lafont

  • Cleveland Clinic Foundation, Cleveland, USA

    Eric J. Topol

Bibliographic Information

  • Book Title: Arterial Remodeling: A Critical Factor in Restenosis

  • Editors: Antoine Lafont, Eric J. Topol

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-6079-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1997

  • Hardcover ISBN: 978-0-7923-8008-5Published: 31 October 1997

  • Softcover ISBN: 978-1-4613-7785-6Published: 11 October 2012

  • eBook ISBN: 978-1-4615-6079-1Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XXIX, 569

  • Topics: Cardiology

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