Arterial Remodeling: A Critical Factor in Restenosis

  • Antoine Lafont
  • Eric J. Topol

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 198)

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Basis of the concept

  3. Restenosis and remodeling: the facts

    1. Front Matter
      Pages 49-49
    2. A. Lafont, E. Durand, S. Drechsel, K. Bougrini, M. Desnos, C. Guérot
      Pages 51-68
    3. Gerard Pasterkamp, Berend Hillen, Cornelius Borst
      Pages 69-80
    4. Gary S. Mintz, Jeffrey J. Popma, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Martin B. Leon
      Pages 111-126
  4. Restenosis and remodeling: the targets revisited

    1. Front Matter
      Pages 159-159
    2. Jean Grégoire, Michael E. Staab, David R. Holmes Jr., Robert S. Schwartz
      Pages 161-180
    3. Gerhard Bauriedel, Sven Schluckebier, Randolph Hutter, Ulrich Welsch, Berndt Lüderitz
      Pages 181-198
    4. Randolph L. Geary, Stephen M. Schwartz
      Pages 199-230
    5. Thomas F. Lüscher, Georg Noll, Chantal M. Boulanger
      Pages 231-252
  5. Molecular aspects of remodeling

    1. Front Matter
      Pages 253-253
    2. Bradford C. Berk
      Pages 277-304
    3. Eric Allaire, Peter Libby, Alexander W. Clowes
      Pages 305-338

About this book

Introduction

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem.
There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion.
The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Keywords

Lipoprotein Stent atherosclerosis coronary artery disease hypertension ultrasound

Editors and affiliations

  • Antoine Lafont
    • 1
  • Eric J. Topol
    • 2
  1. 1.Necker UniversityParisFrance
  2. 2.Cleveland Clinic FoundationClevelandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-6079-1
  • Copyright Information Kluwer Academic Publishers 1997
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7785-6
  • Online ISBN 978-1-4615-6079-1
  • Series Print ISSN 0166-9842
  • About this book