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Identification and Quantification of Chloramphenicol in Medicines by Multisensory Digital Colorimetry

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Moscow University Chemistry Bulletin Aims and scope

Abstract

An effective, affordable, and rapid method for the analysis of drugs based on chloramphenicol is developed using multisensory digital colorimetry. The use of a two-dimensional code for the identification and quantification of chloramphenicol with the minimum level of informational noise is proposed. The principal component analysis is used to increase the reliability of the results of the determination of the medicinal substance. The adequacy of the developed approach is confirmed by the analysis of chloramphenicol preparations in the form of two dosage forms: tablets and eye drops. The accuracy of the results is confirmed by the standard addition method. The results prove that the preparations do not have statistically significant differences from the values declared by the manufacturer.

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Funding

This work was supported by the Russian Science Foundation, project no. 14-23-00012.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    O. V. Monogarova, A. A. Chaplenko & K. V. Oskolok

  2. Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation, 127051, Moscow, Russia

    A. A. Chaplenko

Authors
  1. O. V. Monogarova
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  2. A. A. Chaplenko
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  3. K. V. Oskolok
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Corresponding author

Correspondence to O. V. Monogarova.

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CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

COMPLIANCE WITH ETHICAL STANDARDS

The study was performed without the use of animals and without involving people as subjects.

Additional information

Translated by O. Zhukova

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Monogarova, O.V., Chaplenko, A.A. & Oskolok, K.V. Identification and Quantification of Chloramphenicol in Medicines by Multisensory Digital Colorimetry. Moscow Univ. Chem. Bull. 75, 1–7 (2020). https://doi.org/10.3103/S0027131420010071

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  • DOI: https://doi.org/10.3103/S0027131420010071

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