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Analytical methods for determination of benzodiazepines. A short review

  • Review Article
  • Published:
Central European Journal of Chemistry

Abstract

Benzodiazepines (BDZs) are generally commonly used as anxiolytic and/or hypnotic drugs as a ligand of the GABAA-benzodiazepine receptor. Moreover, some of benzodiazepines are widely used as an anti-depressive and sedative drugs, and also as anti-epileptic drugs and in some cases can be useful as an adjunct treatment in refractory epilepsies or anti-alcoholic therapy. High-performance liquid chromatography (HPLC) methods, thin-layer chromatography (TLC) methods, gas chromatography (GC) methods, capillary electrophoresis (CE) methods and some of spectrophotometric and spectrofluorometric methods were developed and have been extensively applied to the analysis of number of benzodiazepine derivative drugs (BDZs) providing reliable and accurate results. The available chemical methods for the determination of BDZs in biological materials and pharmaceutical formulations are reviewed in this work.

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Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Collegium Medicum of Nicolaus Copernicus University, 85-089, Bydgoszcz, Poland

    Paulina Szatkowska, Marcin Koba, Piotr Kośliński & Jacek Wandas

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland

    Tomasz Bączek

  3. Institute of Health Sciences, Division of Human Anatomy and Physiology, Pomeranian University of Słupsk, 76-200, Słupsk, Poland

    Tomasz Bączek

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  1. Paulina Szatkowska
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  2. Marcin Koba
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Correspondence to Marcin Koba.

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Szatkowska, P., Koba, M., Kośliński, P. et al. Analytical methods for determination of benzodiazepines. A short review. cent.eur.j.chem. 12, 994–1007 (2014). https://doi.org/10.2478/s11532-014-0551-1

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