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Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

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Central European Journal of Chemistry

Abstract

The purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone.

The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours.

The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments.

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References

  1. X. Ding, A.W.G. Alani, J.R. Robinson, Extended release and targeted drug delivery system. In: D.B. Troy, Remington, The Science and Practice of Pharmacy, 21st edition (Lipincott Williams and Wilkins, Philadelphia, 2006)

    Google Scholar 

  2. W. Friess, in: D.M. Brown (Ed.), Biopolymers for parenteral drug delivery in cancer treatment. Drug delivery systems in cancer therapy (Humana Press Inc., Totowa, NJ, 2004)

  3. N. Ahmed, C.E. Mora-Huertas, C. Jaafar-Maalej, H. Fessi, A. Elaissari, in: D. Douroumis, A. Fahr (Eds.), Polymeric drug delivery systems for encapsulating hydrophobic drugs. Drug delivery strategies for poorly water-soluble drugs (John Wiley & Sons Ltd, Oxford, UK, 2013)

  4. A. Kumari, S.K. Yadav, S.C. Yadav, Colloid. Surf. B 75, 1 (2010)

    Article  CAS  Google Scholar 

  5. W. Friess, Eur. J. Pharm. Biopharm. 45, 113 (1998)

    Article  CAS  Google Scholar 

  6. K. Panduranga Rao, J. Biomat. Sci-Polym. E. 7, 623 (1995)

    Article  Google Scholar 

  7. D.G. Wallace, J. Rosenblatt, Adv. Drug Deliver. Rev. 55, 1631 (2003)

    Article  CAS  Google Scholar 

  8. C. Ţârdei, L. Moldovan, O. Crăciunescu, Romanian J. Mater. 40, 41 (2010)

    Google Scholar 

  9. Z. Ruszczak, W. Friess, Adv. Drug De liver. Rev. 55, 1679 (2003)

    Article  CAS  Google Scholar 

  10. K. Fujioka, M. Maeda, T. Hojo, A. Sano, Adv. Drug Deliver. Rev. 31, 247 (1988)

    Article  Google Scholar 

  11. A. Stemberger, H. Grimm, F. Bader, H.D. Rahn, R. Ascherl, J. Surg. Suppl. 578, 17 (1997)

    Google Scholar 

  12. W. Friess, Drug delivery systems based on collagen (Shaker Verlag, Aachen, 2000)

    Google Scholar 

  13. V. Charulatha, A. Rajaram, Biomaterials 24, 759 (2003)

    Article  CAS  Google Scholar 

  14. K. Pal, A.K. Banthia, D.K. Majumdar, Des. Monomers Polym. 12, 197 (2009)

    Article  CAS  Google Scholar 

  15. T.J. Koob, D.J. Hernandez, Biomaterials 23, 203 (2002)

    Article  CAS  Google Scholar 

  16. S-N. Park, J-C. Park, H.O. Kim, M.J. Song, H. Suh, Biomaterials 23, 1205 (2002)

    Article  CAS  Google Scholar 

  17. W.M. Elbjeirami, E.O. Yonter, B.C. Starcher, J.L. West, J. Biomed. Mater. Res. 66A, 513 (2003)

    Article  CAS  Google Scholar 

  18. L. Krishnan, J.A. Weiss, M.D. Wessman, J.B. Hoying, Tissue Eng. 10, 241 (2004)

    Article  CAS  Google Scholar 

  19. K. Belbachir, R. Noreen, G. Gouspillou, G. Petibois, Anal. Bioanal. Chem. 395, 829 (2009)

    Article  CAS  Google Scholar 

  20. F.A. de Jong, J.A. de M. Jonge, J. Verweij, R.H.J. Mathijssen, Cancer Letters 234, 90 (2006)

    Article  Google Scholar 

  21. L.A. de Sousa Rodrigues, A. Figueiras, F. Veiga, R.M. de Freitas, L.C. Cunha Nunes, E.C. da Silva Filho, C.M. da Silva Leite, Colloid. Surf. B 103, 642 (2013)

    Article  Google Scholar 

  22. K.E. Gonsalves, C.R. Halberstadt, C.T. Laurencin, L.S. Nair, Biomedical nanostructures. (Ed. Wiley-Interscience, John Wiley & Sons, Inc., Hoboken, New Jersey, 2008)

    Google Scholar 

  23. P. Chinna Babu, N. Sundaraganesan, S. Sudha, V. Aroulmoji, E. Murano, Spectrochim. Acta A 98, 1 (2012)

    Article  Google Scholar 

  24. M.V. Ghica, M.G. Albu, L. Popa, M. Leca, L. Brăzdaru, C. Cotruţ, V. Trandafir, Rev. Roum. Chim. 54, 1103 (2009)

    CAS  Google Scholar 

  25. E. Andronescu, A. Ficai, M.G. Albu, V. Mitran, M. Sonmez, D. Ficai, R. Ion, A. Cimpean, Technol. Cancer. Res. Treat. 12, 275 (2013)

    CAS  Google Scholar 

  26. M.G. Albu, M. Ferdes, D.A. Kaya, M.V. Ghica, I. Titorencu, L. Popa, Mol. Cryst. Liq. Cryst. 555, 271 (2012)

    Article  CAS  Google Scholar 

  27. Y.A. Lazarev, B.A. Grishkovsky, T.B. Khromova, Biopolymers 24, 1449 (1985)

    Article  CAS  Google Scholar 

  28. B. de Campos Vidal, M.L.S. Mello, Micron. 42, 283 (2011)

    Article  Google Scholar 

  29. M.C. Chang, J. Tanaka, Biomaterials 23, 4811 (2002)

    Article  CAS  Google Scholar 

  30. A. Ficai, M.G. Albu, M. Birsan, M. Sonmez, D. Ficai, V. Trandafir, E. Andronescu, J. Mol. Struct. 1037, 154 (2013)

    Article  CAS  Google Scholar 

  31. N.O. Metreveli, K.K. Jariashvili, L.O. Namicheishvili, D.V. Svintradze, E.N. Chikvaidze, A. Sionkowska, J. Skopinska, Ecotox. Enviro. Safety 73, 448 (2010)

    Article  CAS  Google Scholar 

  32. A. Barth, Ch. Zscherp, Q. Rev. Biophys. 35, 369 (2002)

    Article  CAS  Google Scholar 

  33. Z. Chen, X. Mo, C. He, H. Wang, Carbohydr. Polym. 72, 410 (2008)

    Article  CAS  Google Scholar 

  34. A. Sionkowska, M. Wisniewski, J. Skopinska, C.J. Kennedy, T. Wess, Biomaterials, 25, 795 (2004)

    Article  CAS  Google Scholar 

  35. D. Awa, P. Tardi, X. Xiaowei, L. Maye, Int. J. Pharmaceut. 337, 219 (2007)

    Article  Google Scholar 

  36. K.J. Haglof, E. Popa, H.S. Hochster, Update on Cancer Therapeutics 1, 117 (2006)

    Article  Google Scholar 

  37. A. Ficai, E. Andronescu, D. Ficai, M. Sonmez, M.G. Albu, G Voicu, Cent. Eur. J. Chem. 10, 1949 (2012)

    Article  CAS  Google Scholar 

  38. E. Andronescu, G. Voicu, M. Ficai, I.A. Mohora, R. Trusca, A. Ficai, J. Electron Microsc. 60, 253 (2011)

    Article  CAS  Google Scholar 

  39. M. Ficai, E. Andronescu, D. Ficai, G. Voicu, A. Ficai, Colloid. Surf. B: Biointerfaces 81, 614 (2010)

    Article  CAS  Google Scholar 

  40. R.A. Siegel, M.J. Rathbone, in: J. Siepmann, R.A. Siegel, M.J. Rathbone (Eds.), Overview of Controlled Release Mechanisms. Fundamentals and Applications of Controlled Release Drug Delivery (Springer, NY, 2012)

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Authors and Affiliations

  1. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania

    Georgeta Voicu, Ruxandra E. Geanaliu, Cristina D. Ghiţulică, Anton Ficai & Alexandru M. Grumezescu

  2. S. Nicolau Institute of Virology, 030304, Bucharest, Romania

    Coralia Bleotu

Authors
  1. Georgeta Voicu
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  2. Ruxandra E. Geanaliu
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  3. Cristina D. Ghiţulică
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  4. Anton Ficai
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  5. Alexandru M. Grumezescu
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  6. Coralia Bleotu
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Correspondence to Cristina D. Ghiţulică.

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Voicu, G., Geanaliu, R.E., Ghiţulică, C.D. et al. Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments. cent.eur.j.chem. 11, 2134–2143 (2013). https://doi.org/10.2478/s11532-013-0341-1

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  • DOI: https://doi.org/10.2478/s11532-013-0341-1

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