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An Insight into Collagen-Based Nano Biomaterials for Drug Delivery Applications

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Engineered Biomaterials

Part of the book series: Engineering Materials ((ENG.MAT.))

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Abstract

In modern medicine, drug delivery is a broad field of research for the evolution of novel materials or carrier systems for effective therapeutic delivery of drugs as the controlled drug delivery is a challenge on the basis of solubility, bioavailability, cytotoxicity along with pharmacokinetic parameters.

Protein-based drug delivery systems (DDS) have shown promising results due to structural support, cell-targeted delivery, bioavailability, biocompatibility and non-immunogenicity, etc. Collagen as an important extracellular matrix component has attracted drug delivery-based research in recent years. Collagen based-hydrogels/composites/biofilms are excellent objects for drug delivery, tissue engineering, wound dressings and gene therapeutics etc. due to high encapsulating capacity, mechanically strong swollen structural network and efficient mass transfer properties. Some of the applications of collagen are the formation of microspheres and microneedles for drug delivery, formulation of nanoparticles (NPs) for gene delivery, development of pellets and tablets for protein delivery, formation of gels and combination with liposomes for sustained drug delivery, cancer treatment and collagen shields in ophthalmology.

DDS based on NPs display enhanced efficacy of drugs and improve the drug’s half-life, hydrophobic drug solubility and controlled/sustained drug release in the infected body regions. Stimuli-responsive NPs regulate drug biodistribution and reduce drug toxicity. Protein-based nanocomposites can be prepared through various physical and chemical methods like desolvation, emulsification, phase separation, electrospray, electrospinning and milling, etc. These methods have their operating ease and difficulties for the production of the desired quality of nanomaterials/composites.

Current Polymeric NPs systems are sensitive to stimuli such as temperature, light, pH, oxidizing/reducing agents, magnetic fields and enzymes which increases efficiency and specificity for various applications. Collagen with NPs results in stabilization of the nanoparticles and helps with entrapment of the drug, to attain steady and regulated drug release for ideal therapeutic reactions. Collagen NPs have advantage over other natural and synthetic polymeric NPs due to biocompatibility, biodegradability, low antigenicity, high contact surface and reduced toxicity.

Significant advancements have been achieved using collagen-based nano-DDS to deliver biomolecules with better efficacy at targeted sites. In spite of the substantial progress, collagen is still affected by low mechanical strength and high rate of degradability, which is a serious concern during clinical trials of targeting intracellular molecules like genes, drugs and growth factors, etc. In future, collagen-based nano-DDS will be the key player for the delivery of desired drugs/biomolecules at specific target for different medical conditions.

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  1. Department of Biosciences, Srinivasa Ramanujan Block, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110 025, India

    Amit Kumar Verma

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    Rishabha Malviya

  2. Department of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh, India

    Sonali Sundram

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Verma, A.K. (2023). An Insight into Collagen-Based Nano Biomaterials for Drug Delivery Applications. In: Malviya, R., Sundram, S. (eds) Engineered Biomaterials. Engineering Materials. Springer, Singapore. https://doi.org/10.1007/978-981-99-6698-1_13

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