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Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

  • Research Article
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Central European Journal of Chemistry

Abstract

Three new copper(II) complex compounds with chlorhexidine diacetate as a ligand have been prepared and characterized by elemental and thermogravimetrical analyses, molar conductances, magnetic susceptibility measurements, infrared, electronic and EPR spectra. The complexes correspond to the formulas: [Cu2(CHX)Cl4]·2C2H5OH, [Cu2(CHX)Br4]·2C2H5OH and [Cu2(CHX)(CH3COO)2] (CH3COO)2·2C2H5OH, where CHX = chlorhexidine, their composition and stereochemistry depending on the reaction conditions and the metal salt used. Chlorhexidine acts as neutral tetradentate NNNN donor, coordinating through the four imine nitrogen atoms. Investigations on antimicrobial activity in vitro show that all the complexes are active against the tested microorganisms, the complex with chloride being more active against Gram negative bacteria than chlorhexidine diacetate..

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References

  1. P. Ray, Chem. Rev. 61, 313 (1961)

    Article  CAS  Google Scholar 

  2. J.C.Y. Woo, V.G. Yuen, K.H. Thompson, J.H. McNeill, C. Orvig, J. Inorg. Biochem. 76, 251 (1999)

    Article  CAS  Google Scholar 

  3. D. Sweeney, M.L. Raymer, T.D. Lockwood, Biochem. Pharmacol. 66, 663 (2003)

    Article  CAS  Google Scholar 

  4. L. Patron, M. Giurginca, G.M. Pătrînoiu, N. Iftimie, A. Meghea, Rev. Roum. Chim. 50, 457 (2005)

    CAS  Google Scholar 

  5. G. McDonnell, A.D. Russell, Clin. Microbiol. Rev. 12, 147 (1999)

    CAS  Google Scholar 

  6. M.C. Kudiyirickal, R. Ivančaková, Acta Med. 51, 3 (2008)

    CAS  Google Scholar 

  7. M.J. Jeansonne, R.R. White, J. Endod. 20, 276 (1994)

    Article  CAS  Google Scholar 

  8. D.G. Bates, J.M. Navia, Arch. Oral Biol. 24, 799 (1979)

    Article  CAS  Google Scholar 

  9. K. Skjoerland, P. Gjermo, G. Rolla, Scand. J. Dent. Res. 86, 103 (1978)

    CAS  Google Scholar 

  10. A. Waerhaug, P. Gjermo, G. Rolla, J. Johanssen, J. Clin. Periodont. 11, 176 (1984)

    Article  CAS  Google Scholar 

  11. J.E. Moermann, H.R. Muehlemann, J. Dent. Res. 2, 135 (1983)

    Google Scholar 

  12. S.M. Waler, G. Rolla, Acta Odontol. Scand. 38, 213 (1980)

    Article  CAS  Google Scholar 

  13. C.Gh. Macarovici, Quantitative Inorganic Chemical Analysis (Ed. Acad. RSR, Bucharest, 1979)

    Google Scholar 

  14. S. Singh, R. Malhotra, K.S. Dhindsa, Proc. Nat. Acad. Sci. India 68(A), 217 (1998)

    Google Scholar 

  15. P.V. Babykutty et al., J. Inorg. Nucl. Chem. 36, 3685 (1974)

    Article  CAS  Google Scholar 

  16. R.H. Skabo, P.W. Smith, Aust. J. Chem. 22, 659 (1969)

    CAS  Google Scholar 

  17. P.V. Bharatam, D.S. Patel, P. Iqbal, J. Med. Chem. 48, 7615 (2005)

    Article  CAS  Google Scholar 

  18. K. Nakamoto, Infrared Spectra of Inorganic and Coordination Compounds (Wiley and Sons, New York, 1986)

    Google Scholar 

  19. M. Zhu, L. Lu, P. Yang, X. Jin, Acta Cryst. E 58, 217 (2002)

    Article  Google Scholar 

  20. M. Zhu, L. Lu, P. Yang, X. Jin, Acta Cryst. E 58, 272 (2002)

    Article  Google Scholar 

  21. R. Olar, M. Badea, M.N. Grecu, D. Marinescu, V. Lazar, C. Balotescu, J. Therm. Anal. Calor. 92, 239 (2008)

    Article  CAS  Google Scholar 

  22. R. Olar, M. Badea, E. Cristurean, C. Pârnău, D. Marinescu, J. Therm. Anal. Calor. 84, 53 (2006)

    Article  CAS  Google Scholar 

  23. D.K. Dwivedi, B.V. Agarwala, A.K. Dey, J. Indian Chem. Soc. 65, 461 (1988)

    CAS  Google Scholar 

  24. D. Sen, J. Chem. Soc. A, 2900 (1969)

  25. A.B.P. Lever, Inorganic Electronic Spectroscopy, 2nd edition (Elsevier, Amsterdam-Oxford-New York-Tokyo, 1984)

    Google Scholar 

  26. D. Kivelson, R. Nieman, J. Chem. Phys. 35, 149 (1961)

    Article  CAS  Google Scholar 

  27. P. Bindu, M.R.P. Kurup, T.R. Satyakeerthy, Polyhedron 18, 321 (1999)

    Article  CAS  Google Scholar 

  28. M.F. Hassan, R. Das, A. Khan, M.S. Hossain, M. Rahman, Advan. Biol. Res. 3, 53 (2009)

    Google Scholar 

  29. R.R. Thanigaiarassu, K. Kannabiran, V.G. Khanna, J. Pharm. Res. 2, 273 (2009)

    CAS  Google Scholar 

  30. S. Sasidharan, I. Darah, M.J. Noordin, Indian J. Pharmacol. 40, 227 (2008)

    Article  Google Scholar 

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Authors and Affiliations

  1. Faculty of Chemistry, University of Bucharest, Bucharest, 020462, Romania

    Mirela Călinescu & Octavian Călinescu

  2. Faculty of Pharmacy, Ovidius University, Constanţa, 900470, Romania

    Ticuţa Negreanu-Pîrjol

  3. Research Development National Institute for Physics and Nuclear, Engineering Horia Hulubei, Bucharest-Măgurele, 077125, Romania

    Rodica Georgescu

Authors
  1. Mirela Călinescu
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  2. Ticuţa Negreanu-Pîrjol
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  3. Rodica Georgescu
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  4. Octavian Călinescu
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Correspondence to Mirela Călinescu.

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Călinescu, M., Negreanu-Pîrjol, T., Georgescu, R. et al. Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I. cent.eur.j.chem. 8, 543–549 (2010). https://doi.org/10.2478/s11532-010-0028-9

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  • DOI: https://doi.org/10.2478/s11532-010-0028-9

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