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Copper(II) complexes with N,N-dimethylbiguanide

Thermal, spectroscopic and biological characterization

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Abstract

The N,N-dimethylbiguanide (HDMBG) complexes [Cu2(HDMBG)2Cl4] (1) and respectively [Cu(HDMBG)2]Cl2·2H2O (2) exhibit in vitro antimicrobial activity. The complexes were characterised by IR, electronic as well as EPR spectra. The IR spectra of complexes show the pattern of N,N-dimethylbiguanide coordinated as chelate. The electronic and EPR data are in agreement with a square pyramidal stereochemistry for (1) and a square planar one for (2). The in vitro qualitative and quantitative antimicrobial activity assays showed that the complexes exhibited variable antimicrobial activity against Gram-negative strains (Escherichia coli, Klebsiella spp. and Enterobacter sp.) isolated from the hospital environment.

The thermal analysis has evidenced the thermal intervals of stability and also the thermodynamic effects that accompany them. The thermal behaviour in nitrogen is complex according to TG and DTA curves including melting, dehydration as well as compounds decomposition.

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Authors and Affiliations

  1. Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Sector 5, Bucharest, Romania

    Rodica Olar, Mihaela Badea & Dana Marinescu

  2. National Institute for Materials Physics, P.O. Box MG-7, Bucharest-Magurele, Romania

    Maria Nicoleta Grecu & Carmen Balotescu

  3. Faculty of Biology, Department of Microbiology, University of Bucharest, 1-3 Aleea Portocalilor St., 060101 Sector 6, Bucharest, Romania

    Veronica Lazar

Authors
  1. Rodica Olar
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  2. Mihaela Badea
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  3. Maria Nicoleta Grecu
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  4. Dana Marinescu
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  5. Veronica Lazar
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  6. Carmen Balotescu
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Correspondence to Rodica Olar.

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Olar, R., Badea, M., Grecu, M.N. et al. Copper(II) complexes with N,N-dimethylbiguanide. J Therm Anal Calorim 92, 239–243 (2008). https://doi.org/10.1007/s10973-007-8767-3

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  • DOI: https://doi.org/10.1007/s10973-007-8767-3

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