Abstract
Ticagrelor, an oral antiplatelet agent, is indicated for the prevention of atherothrombotic events in adults with acute coronary syndromes. In this population, ticagrelor was more effective than clopidogrel in preventing ischaemic events over 12 months, providing a significantly lower risk of the primary composite endpoint of myocardial infarction, stroke or death from vascular causes.
Similar content being viewed by others
References
Deeks ED. Ticagrelor: a review of its use in the management of acute coronary syndromes. Drugs 2011; 71(7): 909–33
Bassand JP, Hamm CW, Ardissino D, et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 2007 Jul; 28(13): 1598–660
Van de Werf F, Bax J, Betriu A, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation. The Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008 Dec; 29(23): 2909–45
Brilique 90 mg film-coated tablets: summary of product characteristics. London: European Medicines Agency, 2011 Jan 7
Brillinta™ (ticagrelor) tablets, for oral use: US prescribing information. Wilmington (DE): AstraZeneca LP, 2011 Jul
Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009 Sep 10; 361(11): 1045–57
James S, Åkerblom A, Cannon CP, et al. Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J 2009 Apr; 157(4): 599–605
James S, Budaj A, Aylward P, et al. Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the PLATelet inhibition and patient Outcomes (PLATO) trial. Circulation 2010 Sep 14; 122(11): 1056–67
James S, Angiolillo DJ, Cornel JH, et al. Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J 2010 Dec; 31(24): 3006–16
Wallentin L, James S, Storey RF, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 2010 Oct 16; 376(9749): 1320–8
Cannon CP, Harrington RA, James S, et al. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet 2010 Jan 23; 375(9711): 283–93
Steg PG, James S, Harrington RA, et al. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a PLATelet inhibition and patient Outcomes (PLATO) trial subgroup analysis. Circulation 2010 Nov 23; 122(21): 2131–41
Storey RF, Becker RC, Cannon CP, et al. Ticagrelor does not affect pulmonary function tests compared to clopidogrel in acute coronary syndromes: results of the PLATO pulmonary substudy [abstract no. 1100-276]. J Am Coll Cardiol 2010 Mar 9; 55: A108: E1007
Varenhorst C, Alstrom U, Scirica BM, et al. Cardiac events, infections and bleed contribute to higher vascular and non-vascular mortality with clopidogrel compared to ticagrelor treatment in patients undergoing coronary artery bypass grafting [abstract no. P2428]. Eur Heart J 2011; 32Suppl. 1: 414
Final appraisal determination: ticagrelor for the treatment of acute coronary syndromes. London: National Institute for Health and Clinical Excellence, 2011 Sep
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Scott, L.J., Deeks, E.D. Ticagrelor: a guide to its use in the management of acute coronary syndromes. Drugs Ther Perspect 28, 1–5 (2012). https://doi.org/10.2165/11606170-000000000-00000
Published:
Issue Date:
DOI: https://doi.org/10.2165/11606170-000000000-00000