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Effects of Atenolol and Propranolol on Glucose Metabolism and Hormonal Responses during Insulin-induced Hypoglycaemia in Normal Man

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Summary

Propranolol and, to a lesser extent, atenolol, prolong hypoglycaemia after insulin administration. The prolonged hypoglycaemia after propranolol was caused by increased tissue glucose uptake which was not counteracted by increased glucose release. Hypoglycaemia was accompanied by a marked diastolic pressor and bradycardic response during propranolol, but not atenolol, administration.

It is suggested that the increased glucose uptake after propranolol administration takes place in the muscles and is caused by the antilipolytic effect of the drug leading to lower free fatty acid concentrations and thereby facilitating muscle glucose uptake.

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Authors and Affiliations

  1. Medical Department C, Bispebjerg Hospital, Copenhagen, Denmark

    J. Lyngsøe, U. Birk Lauridsen & N. J. Christensen

  2. Department of Internal Medicine and Endocrinology, Herlev Hospital, Herlev, Denmark

    J. Lyngsøe & N. J. Christensen

Authors
  1. J. Lyngsøe
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  2. U. Birk Lauridsen
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  3. N. J. Christensen
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Lyngsøe, J., Lauridsen, U.B. & Christensen, N.J. Effects of Atenolol and Propranolol on Glucose Metabolism and Hormonal Responses during Insulin-induced Hypoglycaemia in Normal Man. Drugs 25 (Suppl 2), 237–240 (1983). https://doi.org/10.2165/00003495-198300252-00068

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  • DOI: https://doi.org/10.2165/00003495-198300252-00068

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