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Electrochemistry of Metoclopramide at Multi-walled Carbon Nanotube Modified Electrode and Its Voltammetric Detection

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Abstract

A simple, sensitive and inexpensive electrochemical method was developed for the determination of metoclopramide (MCP) with a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE). MWNT was dispersed into polyacrylic acid (PAA); the aqueous suspension was then cast on GCE electrodes, forming MWNT-PAA films after evaporation of the solvent. The electrochemical behavior of MCP at the MWNT-modified electrode was investigated in detail. Compared with the bare GCE, the MWNT-modified electrode exhibits electrocatalytic activity to the oxidation of MCP because of the significant oxidation peak-current enhancement. Furthermore, various experimental parameters, such as the solution pH value, the amount of MWNT-PAA suspension and accumulation conditions were optimized for the determination of MCP. Based on the electrocatalytic effect of the MWNT-modified electrode, linear sweep voltammetry (LSV) was developed for the determination of MCP with the linear response in the range from 1.0 × 10−7 to 1.0 × 102212;5 mol L2212;1 and a detection limit of 5.0 × 102212;8 mol L2212;1. The method has been successfully applied to the determination of MCP in commercial MCP tablets.

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Authors and Affiliations

  1. Department of Chemistry, Xinxiang Medical University, East of JinSui Road, Xinxiang, Henan, 453003, P. R. China

    Wei Guo & Mingjiang Geng

  2. College of Resource and Environment, Henan Institute of Science and Technology, East of HuaLan Road, Xinxiang, Henan, 453003, P. R. China

    Lingyun Zhou

Authors
  1. Wei Guo
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  2. Mingjiang Geng
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  3. Lingyun Zhou
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Correspondence to Mingjiang Geng.

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Guo, W., Geng, M. & Zhou, L. Electrochemistry of Metoclopramide at Multi-walled Carbon Nanotube Modified Electrode and Its Voltammetric Detection. ANAL. SCI. 28, 693–698 (2012). https://doi.org/10.2116/analsci.28.693

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  • DOI: https://doi.org/10.2116/analsci.28.693

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