Abstract
Prostate cancer (PCa) is a pernicious tumor with high heterogeneity, which creates a conundrum for making a precise diagnosis and choosing an optimal treatment approach. Multiparametric magnetic resonance imaging (mp-MRI) with anatomical and functional sequences has evolved as a routine and significant paradigm for the detection and characterization of PCa. Moreover, using radiomics to extract quantitative data has emerged as a promising field due to the rapid growth of artificial intelligence (AI) and image data processing. Radiomics acquires novel imaging biomarkers by extracting imaging signatures and establishes models for precise evaluation. Radiomics models provide a reliable and noninvasive alternative to aid in precision medicine, demonstrating advantages over traditional models based on clinicopathological parameters. The purpose of this review is to provide an overview of related studies of radiomics in PCa, specifically around the development and validation of radiomics models using MRI-derived image features. The current landscape of the literature, focusing mainly on PCa detection, aggressiveness, and prognosis evaluation, is reviewed and summarized. Rather than studies that exclusively focus on image biomarker identification and method optimization, models with high potential for universal clinical implementation are identified. Furthermore, we delve deeper into the critical concerns that can be addressed by different models and the obstacles that may arise in a clinical scenario. This review will encourage researchers to design models based on actual clinical needs, as well as assist urologists in gaining a better understanding of the promising results yielded by radiomics.
摘要
前列腺癌(PCa)是一种具有高度异质性的恶性肿瘤, 这给PCa的精准诊断和最佳个性化治疗带来了难题. 具备解剖和功能序列的多参数磁共振成像(mp-MRI)已经发展成为PCa检测和分期的重要工具. 此外, 随着人工智能(AI)和图像数据处理技术的快速发展, 利用影像组学的方法定量提取医学影像数据迎来广阔的应用前景. 影像组学通过提取影像特征来获得影像标志物, 并在此基础上建立预测模型进行精确评估. 影像组学模型提供了一个辅助精准医疗的可靠且无创的替代方案, 较基于临床病理指标的传统模型具有明显优势. 本综述致力于对PCa影像组学相关研究进行归纳总结, 重点探讨了基于MRI的影像组学模型的开发和验证. 本综述对有关PCa诊断、 侵袭性和预后评估方面的影像组学预测模型相关文献进行了回顾和总结, 重点关注具有临床应用潜力的预测模型. 此外, 我们深入探讨了不同模型可以解决的关键问题, 以及在具体临床背景下可能遇到的困难. 因此, 本综述有助于鼓励研究人员根据实际的临床需求构建预测模型, 并帮助泌尿外科医生更好地了解影像组学相关的重要研究成果.
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Acknowledgments
This work was supported by the Beijing Natural Science Foundation (Nos. Z200027 and L212051), the Cohort Construction Project of Peking University Third Hospital (No. BYSYDL2021012), the Medicine-X Project of Peking University Health Science Center (No. BMU2022MX014), and the National Natural Science Foundation of China (No. 61871004).
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Xuehua ZHU, Lizhi SHAO, Zenan LIU, and Jide HE searched the literature; Xuehua ZHU and Lizhi SHAO drafted the manuscript; Zhenyu LIU, Jiangang LIU, Hao PING, and Jian LU contributed to the design and revision of this manuscript. All authors have read and approved the final manuscript.
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Xuehua ZHU, Lizhi SHAO, Zhenyu LIU, Zenan LIU, Jide HE, Jiangang LIU, Hao PING, and Jian LU declare that they have no conflict of interest.
This review does not contain any studies with human or animal subjects performed by any of the authors.
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Zhu, X., Shao, L., Liu, Z. et al. MRI-derived radiomics models for diagnosis, aggressiveness, and prognosis evaluation in prostate cancer. J. Zhejiang Univ. Sci. B 24, 663–681 (2023). https://doi.org/10.1631/jzus.B2200619
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DOI: https://doi.org/10.1631/jzus.B2200619