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Investigation on bioactivity, mechanical stability, bactericidal activity and in-vitro biocompatibility of magnesium silicates for bone tissue engineering applications

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Abstract

The current work reports the biocompatibility and mechanical stability of enstatite and forsterite bioceramics prepared by sol–gel combustion method. XRD results conferred that enstatite and forsterite phase formation take place at 1000 °C and 900 °C respectively. TEM micrographs indicated the particle size of enstatite in the micron range while forsterite is in the range of 100–200 nm. The FT-IR spectra of forsterite after biomineralization revealed the presence of phosphate and carbonate groups shows apatite deposition ability of forsterite. The slow degradation and better apatite deposition of forsterite resulted in ten folds greater compressive strength than enstatite. Both the bioceramics have shown a remarkable impact on inhibiting the growth of clinical pathogens at a very low concentration. The good hBMSCs attachment and significant proliferation revealed the cytocompatibility of enstatite and forsterite. These observations suggested that magnesium silicate bioceramics can be explored for load-bearing applications, maxillofacial reconstruction and septic arthritis.

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Acknowledgments

The authors acknowledge the Vellore Institute of Technology (VIT) management for the support and CAMPT-VIT for helping with the mechanical studies. The authors also thank DST-FIST for the XRD and SEM-EDX facility. The authors gratefully acknowledge the financial support from the European Union’s Horizon 2020 research and innovation program under the grant agreement No. 857287.The authors would like to express their highest gratitude to Ministry of Higher Education for fundamental research grant scheme (FRGS)—FRGS/1/2016/SKK08/UM/02/20.

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Authors and Affiliations

  1. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India

    Senthil Kumar Venkatraman, Naveensubramaniam Vijayakumar & Sasikumar Swamiappan

  2. Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, Tamil Nadu, India

    Senthil Kumar Venkatraman

  3. Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General, Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka Street 3, Riga, LV-1007, Latvia

    Rajan Choudhary

  4. Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Kalku Street 1, Riga, LV-1658, Latvia

    Rajan Choudhary

  5. Central Research Facility, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, Tamil Nadu, India

    Hanumantha Rao Balaji Raghavendran

  6. Microbial Biotechnology Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India

    Anushree Suresh & Jayanthi Abraham

  7. Tissue Engineering Group (TEG), Department of Orthopaedic Surgery (NOCERAL), Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Genasan Krishnamurithy, Hanumantha Rao Balaji Raghavendran, Malliga Raman Murali & Tunku Kamarul

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  1. Senthil Kumar Venkatraman
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  2. Rajan Choudhary
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Correspondence to Sasikumar Swamiappan.

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Venkatraman, S.K., Choudhary, R., Vijayakumar, N. et al. Investigation on bioactivity, mechanical stability, bactericidal activity and in-vitro biocompatibility of magnesium silicates for bone tissue engineering applications. Journal of Materials Research 37, 608–621 (2022). https://doi.org/10.1557/s43578-021-00450-9

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