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Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO–CaO–SiO2 system

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Abstract

The aim of this research was to investigate the effect of the chemical composition on the mechanical properties, bioactivity, and cytocompatibility in vitro of bioceramics in the MgO–CaO–SiO2 system. Three single-phase ceramics (merwinite, akermanite and monticellite ceramics) with different MgO contents were fabricated. The mechanical properties were tested by an electronic universal machine, while the bioactivity in vitro of the ceramics was detected by investigating the bone-like apatite-formation ability in simulated body fluid (SBF), and the cytocompatibility was evaluated through osteoblast proliferation and adhesion assay. The results showed that their mechanical properties were improved from merwinite to akermanite and monticellite ceramics with the increase of MgO contents, whereas the apatite-formation ability in SBF and cell proliferation decreased. Furthermore, osteoblasts could adhere, spread and proliferate on these ceramic wafers. Finally, the elongated appearance and minor filopodia of cells on merwinite ceramic were more obvious than the other two ceramics.

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Acknowledgments

Financial supports from the Fund for Excellent Young Researchers of the Sichuan Province, China (07ZQ026-118) are gratefully acknowledged.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, Sichuan, People’s Republic of China

    Xianchun Chen, Jun Ou, Yan Wei, Zhongbing Huang, Yunqing Kang & Guangfu Yin

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  1. Xianchun Chen
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  2. Jun Ou
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  3. Yan Wei
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  4. Zhongbing Huang
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  5. Yunqing Kang
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  6. Guangfu Yin
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Correspondence to Guangfu Yin.

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Chen, X., Ou, J., Wei, Y. et al. Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO–CaO–SiO2 system. J Mater Sci: Mater Med 21, 1463–1471 (2010). https://doi.org/10.1007/s10856-010-4025-5

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  • DOI: https://doi.org/10.1007/s10856-010-4025-5

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