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Simulations of Stretching Single Stranded DNA

  • Multiscale Mechanics of Hierarchical Biological, Bioinspired, and Biomedical Materials
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Abstract

Molecular dynamics simulations were performed to estimate sequence dependent force required to stretch single stranded DNA (ssDNA) homo oligonucleotides. Simulations suggest that polyA and polyC oligonucleotides exhibit similar force profiles and corresponding elongation. Among single stranded DNA strands polyT is the most flexible and needs the most force to unwind from an equilibrium folded structure. In contrast, polyG had a very small recoverable deformation prior to a non-linear stretching. Our results indicate that mechanical properties of ssDNA chains are directly related to their sequence.

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Authors and Affiliations

  1. Materials Science and Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, 27695, USA

    Abhishek Singh & Yaroslava G. Yingling

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  1. Abhishek Singh
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  2. Yaroslava G. Yingling
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Singh, A., Yingling, Y.G. Simulations of Stretching Single Stranded DNA. MRS Online Proceedings Library 1301, 143–147 (2011). https://doi.org/10.1557/opl.2011.569

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  • DOI: https://doi.org/10.1557/opl.2011.569

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