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Materials that harness and modulate the immune system

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Abstract

Recently, biomaterial scientists have married materials engineering and immunobiology to conceptualize new immunomodulatory materials. This special class of biomaterials can modulate and harness the innate properties of immune functionality for enhanced therapeutic efficacy. Generally, two fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-evasive (immuno-mimetic, immuno-suppressing, or immuno-inert) biomaterials and (2) immuno-activating or immuno-enhancing biomaterials. This article highlights the development and application of a number of immunomodulatory materials, categorized by these two general approaches.

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Acknowledgments

This work was supported in part by grants from the National Institutes of Health, R01DK091658 and R21A1094360.

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Authors and Affiliations

  1. University of Florida, Gainesville, USA

    Jamal S. Lewis & Benjamin G. Keselowsky

  2. University of Texas at Austin, USA

    Krishnendu Roy

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  1. Jamal S. Lewis
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Correspondence to Jamal S. Lewis.

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Lewis, J.S., Roy, K. & Keselowsky, B.G. Materials that harness and modulate the immune system. MRS Bulletin 39, 25–34 (2014). https://doi.org/10.1557/mrs.2013.310

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