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Surface treatment of titanium by anodization and iron deposition: mechanical and biological properties

  • Biomedical Materials, Regenerative Medicine and Drug Delivery
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Abstract

Surface modification of titanium and titanium alloys is a common method to improve anchoring of bone tissue and implants in hard tissue engineering applications. In the current work, a combination of chemical and physical methods (anodization and physical vapor deposition) was used to roughen the titanium surface and deposit iron (Fe) on the surface of titanium at different thicknesses. The optimized thickness of 100 Å was selected for mechanical and biological characterization. We found that anodization increases the surface roughness of Ti from 21 ± 0 to 229 ± 9 nm, whereas Fe deposition does not change it significantly. Our results also showed that surface modification of Ti by anodization increases the proliferation of osteosarcoma cells at both time points, whereas Fe-deposited samples showed the lowest cellular activity. These results suggest that Fe-deposited Ti implants may be suitable candidates for patients with osteosarcoma, as the proliferation of malignant cells decreases in the presence of Fe.

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Acknowledgments

We acknowledge Dr. Michael HajiSheikh and Mr. Gregg Westberg (Microelectronics Research and Development Lab) at Northern Illinois University and Dr. Q. Jane Wang at Northwestern University. We also thank College of Engineering and Engineering Technology and Division of Research and Innovation Partnerships for supporting this research. N.S. Lin is a high-school summer research volunteer from Milton High School, Milton, GA30004, USA.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Northern Illinois University, DeKalb, Illinois, 60115, USA

    Murali Krishna Duvvuru & Sahar Vahabzadeh

  2. Department of Mechanical Engineering, Northwestern University, Evanston, Illinois, 60208, USA

    Lupeng Wu

  3. Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois, 60115, USA

    Nicole S. Lin & Tao Xu

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  1. Murali Krishna Duvvuru
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  2. Lupeng Wu
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  5. Sahar Vahabzadeh
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Correspondence to Sahar Vahabzadeh.

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Duvvuru, M.K., Wu, L., Lin, N.S. et al. Surface treatment of titanium by anodization and iron deposition: mechanical and biological properties. Journal of Materials Research 35, 1290–1297 (2020). https://doi.org/10.1557/jmr.2020.107

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