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In vivo performance analysis of silanized and coated nitinol wires in biological environment

  • Biomedical Materials, Regenerative Medicine and Drug Delivery
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Abstract

Some interesting properties such as superelasticity, shape memory effect, kink resistance, good biocompatibility, biomechanical properties, and corrosion resistance made nitinol a popular biomaterial as stent and orthopedic implants. But surface modification is needed to control nickel leaching from its surface, making safe for human body. The aim of this study was to modify the nitinol surface by the silanization technique and electrophoretically deposited hydroxyapatite coating, and to conduct a detailed in vitro and in vivo investigation. Detailed in vitro investigation involved MTT assay with the human osteoblastic cells (MG63 cell) over a period of 5 days and confocal image study. In case of in vivo study, histological study, fluorochrome labeling study, and Micro-Ct study were conducted. The overall in vitro and in vivo results indicate that silanized nitinol samples are showing slightly better level of performance, but both the surface-modified samples are suitable as the potential bio-implant for orthopedic purpose.

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Acknowledgments

One of the authors Sarmita Sinha would like to acknowledge the Council of Scientific and Industrial Research. The authors wish to express their thanks to the Honorable Vice-Chancellor of West Bengal University of Animal and Fishery Sciences, Kolkata, India. Authors also acknowledge Mechanical Engineering Department and School of Bio Science & Engineering, Jadavpur University, Kolkata, India, for their support to use the facilities for the experimentation. Mangal Roy would like to acknowledge technical personnel at the Central Facility, IIT-Kharagpur, for their support in µ-CT analysis.

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Author notes

  1. Karuppasamy Bavya Devi

    Present address: Department of Chemistry, Nims Institute of Engineering & Technology, Nims University Rajasthan, Jaipur-Delhi Highway (NH-11C), Nims Institute of Engineering & Technology, Jaipur, Rajasthan, 303121, India

Authors and Affiliations

  1. Department of Mechanical Engineering, Jadavpur University, Kolkata, 700032, India

    Sarmita Sinha & Abhijit Chanda

  2. School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, Kharagpur, 721302, India

    Jyotsana Priyadarshani & Soumen Das

  3. Department of Metallurgical and Materials Engineering, Indian Institute of Technology-Kharagpur, Kharagpur, 721302, India

    Karuppasamy Bavya Devi & Mangal Roy

  4. Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, 700037, India

    Anyam Vijay Kishore, Piyali Das & Samit Kumar Nandi

Authors
  1. Sarmita Sinha
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  2. Jyotsana Priyadarshani
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Correspondence to Abhijit Chanda or Samit Kumar Nandi.

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Sinha, S., Priyadarshani, J., Devi, K.B. et al. In vivo performance analysis of silanized and coated nitinol wires in biological environment. Journal of Materials Research 35, 1262–1270 (2020). https://doi.org/10.1557/jmr.2020.101

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  • DOI: https://doi.org/10.1557/jmr.2020.101

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