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Improved performance of the functionalized nitinol as a prospective bone implant material

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Abstract

Nitinol, being a shape memory and super elastic alloy, is used in medical industry. Surface modification of nitinol helps to reduce the nickel ion leaching in physiological environment. The purpose of this study is to modify the nitinol surface by the silanization technique and to conduct a comparative investigation with the bare nitinol in the aspect of leaching of nickel ion, hemocompatibility, and in vivo animal response. X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy studies confirmed the addition of organofunctional alkoxysilane molecules through the silanization process. The histological study showed the presence of adequate number of osteoblasts in silanized nitinol. The fluorochrome labeling study depicted more new bone formation (8 and 21% higher) in silanized nitinol specimens than bare one at one and three months postoperatively. Radiology and SEM study also proved the better performance of silanized samples. The cumulative in vivo results indicate its suitability as the potential bioimplant in various orthopedic surgical uses.

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ACKNOWLEDGMENTS

One of the authors (Sarmita Sinha) would like to acknowledge Council of Scientific and Industrial Research for financial support. The authors also acknowledge support from Mechanical Engineering Department and School of Bio Science & Engineering, Jadavpur University, Kolkata. The kind support from the Honorable Vice Chancellor, West Bengal University of Animal and Fishery Sciences, is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Jadavpur University, Kolkata, 700032, India

    Sarmita Sinha & Abhijit Chanda

  2. School of Bioscience and Engineering, Jadavpur University, Kolkata, 700032, India

    Howa Begam

  3. Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, 700037, India

    Vinod Kumar & Samit Kumar Nandi

  4. A. Chełkowski Institute of Physics, University of Silesia, Katowice, 40-007, Poland

    Jerzy Kubacki

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  1. Sarmita Sinha
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  2. Howa Begam
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  3. Vinod Kumar
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  4. Samit Kumar Nandi
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  6. Abhijit Chanda
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Correspondence to Samit Kumar Nandi or Abhijit Chanda.

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Sinha, S., Begam, H., Kumar, V. et al. Improved performance of the functionalized nitinol as a prospective bone implant material. Journal of Materials Research 33, 2554–2564 (2018). https://doi.org/10.1557/jmr.2018.204

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