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Programmed Death of Microglia in Alzheimer’s Disease: Autophagy, Ferroptosis, and Pyroptosis

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Increasing evidence has demonstrated that the damage of cell plays an important role in AD. Cell death is a critical phenomenon for physiological functions, which promotes AD pathogenesis. Programmed cell death, including necroptosis, pyroptosis, autophagy, and ferroptosis, have been discovered that have unique biological functions and pathophysiological characteristics. Here, we review the available evidence detailing the mechanisms of programmed microglial death, including pyroptosis, autophagy, and ferroptosis. We also highlight the role of programmed death of microglia during the process of AD and focus on the connection between the disease and cell death.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China [82001473].

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Authors and Affiliations

  1. Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China

    Z. Qiu, H. Zhang, M. Xia, J. Gu, K. Guo, H. Wang & Changhong Miao

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  1. Z. Qiu
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  2. H. Zhang
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  3. M. Xia
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  4. J. Gu
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  5. K. Guo
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  6. H. Wang
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  7. Changhong Miao
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Correspondence to Changhong Miao.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Zhongshan Hospital of Fudan university.

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Qiu, Z., Zhang, H., Xia, M. et al. Programmed Death of Microglia in Alzheimer’s Disease: Autophagy, Ferroptosis, and Pyroptosis. J Prev Alzheimers Dis 10, 95–103 (2023). https://doi.org/10.14283/jpad.2023.3

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  • DOI: https://doi.org/10.14283/jpad.2023.3

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