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Ferroptosis and Its Role in Diverse Brain Diseases

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Abstract

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer’s disease, and Parkinson’s disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.

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Acknowledgments

We thank Dr. Fei Yang from Capital Medical University for valuable comments and suggestions. We thank Claire Levine, MS, ELS, for assistance with manuscript editing.

Funding

This review paper was supported by American Heart Association Postdoctoral Fellowship Award 17POST33660191 to XL, American Heart Association Scientist Development Grant 16SDG30980031 to XH, and the Scientific Research Program of Beijing Municipal Commission of Education (grant no. KM201710025005 to YW). JW is supported by the National Institutes of Health (R21NS102899) and a Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, John Hopkins University.

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Authors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Abigail Weiland, Xi Lan, Xiaoning Han & Jian Wang

  2. Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Neural Regeneration and Repair, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China

    Yamei Wang, Weihua Wu & Qian Li

  3. Advanced Innovation Center for Human Brain Protection, Captical Medical University, Beijing, 100069, China

    Qian Li

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  7. Jian Wang
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AW, YW, WW, QL, and JW wrote the manuscript; AW, YW, XH, XL, QL, and JW revised the manuscript.

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Correspondence to Qian Li or Jian Wang.

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Weiland, A., Wang, Y., Wu, W. et al. Ferroptosis and Its Role in Diverse Brain Diseases. Mol Neurobiol 56, 4880–4893 (2019). https://doi.org/10.1007/s12035-018-1403-3

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  • DOI: https://doi.org/10.1007/s12035-018-1403-3

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