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Secretion of inhibin A and inhibin B during pregnancy and early postpartum period in Japanese monkeys

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Abstract

In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin α-, βA-, and βB-subunits by immunohistochemistry. Serum concentrations of inhibin A showed a significant rise at the second quarter and maintained its level until term. Serum concentrations of inhibin B gradually increased until the fourth quarter. The concentration of both inhibins abruptly declined after delivery to the nonpregnant level. Positive staining of inhibin α-, βA-, and βB-subunits was observed in syncytiotrophoblast in the placenta by immunohistochemistry. These results demonstrated that large amounts of both dimeric inhibins are secreted from the placenta of Japanese monkeys.

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Authors and Affiliations

  1. Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan

    Masahiro Kondo, WanZhu Jin, Gen Watanabe & Kazuyoshi Taya Ph.D.

  2. Primate Research Institute, Kyoto University, Aichi, Japan

    Keiko Shimizu & Mariko Itoh

  3. School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK

    N. P. Groome

  4. Laboratory of Veterinary Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu, Tokyo, Japan

    Chihiro Kojima, Gen Watanabe & Kazuyoshi Taya Ph.D.

Authors
  1. Chihiro Kojima
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  2. Masahiro Kondo
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  3. WanZhu Jin
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  4. Keiko Shimizu
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  5. Mariko Itoh
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  6. Gen Watanabe
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  7. N. P. Groome
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  8. Kazuyoshi Taya Ph.D.
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Correspondence to Kazuyoshi Taya Ph.D..

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Kojima, C., Kondo, M., Jin, W. et al. Secretion of inhibin A and inhibin B during pregnancy and early postpartum period in Japanese monkeys. Endocr 18, 21–25 (2002). https://doi.org/10.1385/ENDO:18:1:21

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  • DOI: https://doi.org/10.1385/ENDO:18:1:21

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