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The Na,K-ATPase receptor complex

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Abstract

A major difference between the Na,K-ATPase ion pump and other P-type ATPases is its ability to bind cardiotonic steroids such as ouabain. Na,K-ATPase also interacts with many membrane and cytosolic proteins. In addition to their role in Na,K-ATPase regulation, it became apparent that some of the newly identified interactions are capable of organizing the Na,K-ATPase into various signaling complexes. This new function confers a ligand-like effect to cardiotonic steroids on cellular signal transduction. This article reviews these new developments and provides a comparison of Na,K-ATPase-mediated signal transduction with other receptors and ion transporters.

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  1. Department Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, 43614, Toledo, OH

    Sandrine V. Pierre & Zijian Xie

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  1. Sandrine V. Pierre
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  2. Zijian Xie
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Correspondence to Zijian Xie.

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Pierre, S.V., Xie, Z. The Na,K-ATPase receptor complex. Cell Biochem Biophys 46, 303–315 (2006). https://doi.org/10.1385/CBB:46:3:303

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