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Na/K-ATPase and Its Role in Signal Transduction

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Regulation of Membrane Na+-K+ ATPase

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 15))

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Abstract

The Na/K-ATPase was discovered as an essential ion pump that maintains intracellular ionic balance by transporting potassium and sodium ions into and out of eukaryotic cells at the expense of ATP. The efforts of numerous investigators during the last two decades have revealed several important non-pumping functions of Na/K-ATPase. This chapter focuses on the molecular mechanism of Na/K-ATPase-mediated signal transduction and its potential regulatory role in animal physiology and diseases.

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Authors and Affiliations

  1. Marshall Institute for Interdisciplinary Research (MIIR), Robert C Byrd Biotechnology Center, Marshall University, 1700 Third Avenue, Suite 220, Huntington, WV, 25755, USA

    Moumita Banerjee & Zijian Xie

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  1. Moumita Banerjee
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  2. Zijian Xie
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Correspondence to Zijian Xie .

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  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Banerjee, M., Xie, Z. (2016). Na/K-ATPase and Its Role in Signal Transduction. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_2

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