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Study on Improving the Performance of Traditional Medicine Extracts with High Drug Loading Based on Co-spray Drying Technology

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Abstract

The purpose of this study is to develop modified particles with different structures to improve the flowability and compactibility of Liuwei Dihuang (LWDH) powder using co-spray drying technology, and to investigate the preparation mechanism of modified particles and their modified direct compaction (DC) properties. Moreover, tablets with high drug loading contents were also prepared. Particles were designed using polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC E3) as shell materials, and sodium bicarbonate (NaHCO3) and ammonium bicarbonate (NH4HCO3) as pore-forming agents. The porous particles (Ps), core-shell particles (CPs), and porous core-shell particles (PCPs) were prepared by co-spray drying technology. The key DC properties and texture properties of all the particles were measured and compared. The properties of co-spray drying liquid were also determined and analyzed. According to the results, Ps showed the least improvement in DC properties, followed by CPs, and PCPs showed a significant improvement. The modifier, because of its low surface tension, was wrapped in the outer layer to form a shell, and the pore-forming agent was thermally decomposed to produce pores, forming core-shell, porous, and porous core-shell composite structures. The smooth surface of the shell structure enhances fluidity, while the porous structure allows for greater compaction space, thereby improving DC properties during the compaction process.

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Data Availability

The data generated and analyzed in the study are included in this article. Any additional supportive data are available on request from the corresponding author, upon reasonable request.

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Acknowledgements

We are grateful to Jiang Zhong Pharmaceutical Co., Ltd. for their support in the extraction and concentration of Chinese medicinal materials. We are also grateful to the Key Laboratory of Jiangxi University of Chinese Medicine for supporting the determination of key properties of the powder by DC.

Funding

This research was funded by the National Natural Science Foundation of China (82003953, 82360777), China Postdoctoral Science Foundation (2019M662278), National Natural Science Foundation of Jiangxi Province (20202BAB216039, 20232ACB216015, 20212BAB216009, and 20232BAB206166), 2020–2022 Young Talents Support Project of Chinese Society of Chinese Medicine (2020-QNRC2-07), Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program (CXTD-22004), Doctoral Research Start-up Fund Project of Jiangxi University of Chinese Medicine (2021BSZR015, 2022BSZR003), Training Plan for Academic and Technical Leaders of Major Disciplines in Jiangxi Province (20204BCJL22048), and 2023 Innovation and Entrepreneurship Training Program of Jiangxi University of Chinese Medicine (X202310412208).

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  1. Zhe Li and Wanghai Peng contributed equally.

Authors and Affiliations

  1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang, 330004, People’s Republic of China

    Zhe Li, Wanghai Peng, Lihua Chen, Abid Naeem, Weifeng Zhu, Yi Feng & Liangshan Ming

  2. Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, People’s Republic of China

    Lin Zhu

  3. Jiangzhong Pharmaceutical Co. Ltd, Nanchang, 330049, People’s Republic of China

    Wenjun Liu & Lingyu Yang

  4. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Yi Feng

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Contributions

ZL conceived/designed the study. ZL, WP, and LZ carried out the experiments and data collection. LC, AN, and YF carried out the analysis and interpretation of data. WP, LZ, WL, and LY drafted the manuscript. ZL, WZ, and LM revised and critically reviewed the work for important intellectual content and gave final approval of the version for publication.

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Correspondence to Liangshan Ming.

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Li, Z., Peng, W., Zhu, L. et al. Study on Improving the Performance of Traditional Medicine Extracts with High Drug Loading Based on Co-spray Drying Technology. AAPS PharmSciTech 24, 247 (2023). https://doi.org/10.1208/s12249-023-02703-8

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