Abstract
Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited. Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs. In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X). Their physical properties were characterized comprehensively. The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly. The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time. The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs. These findings are beneficial to the development of herbal core-shell CPs for DC.
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Abbreviations
- Ad:
-
Adhesiveness
- AR:
-
Angle of repose
- AUC:
-
Area under curve
- AUTCC:
-
The area under tensile strength versus compaction force curve
- CF:
-
Compaction force
- ChP:
-
Chinese Pharmacopeia
- CI:
-
Carr’s index
- Co:
-
Cohesiveness
- CP:
-
Composite particle
- CP X-H:
-
Composite particles containing HPMC
- CP X-P:
-
Composite particles containing PVP
- CR:
-
Compaction ratio
- d(0.5):
-
Median particle size
- E SP :
-
Net energy per unit of quality
- F :
-
Breaking force
- f :
-
Equilibrium hygroscopic moisture content
- Ha:
-
Hardness
- HPMC/H:
-
Hydroxypropyl methylcellulose
- HR:
-
Hausner ratio
- k :
-
Moisture absorption constant
- MC:
-
Moisture content
- PL:
-
Percentage of net energy except friction energy
- PM:
-
Physical mixture
- PVP/P:
-
Polyvinylpyrrolidone
- P y :
-
Yield pressure
- ρ b :
-
Bulk density
- ρ t :
-
Tapped density
- ρ true :
-
True density
- Re:
-
Resilience
- R 2 :
-
Square of the correlation coefficient
- Sp:
-
Springiness
- Span:
-
Particle size distribution
- TS:
-
Tensile strength
- Un:
-
Uniformity
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Funding
This work was funded by the National Natural Science Foundation of China (81973490), China; Natural Science Foundation of Shanghai (18ZR1439800, 18ZR1436600), China; China Postdoctoral Science Foundation (2019 M662278), China; Construction of Collaborative Innovation Center of Shanghai (2020-Sci&Tec-01-01-30), China; Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ190688), China; Three-year Action Plan for the Development of Traditional Chinese Medicine of Shanghai Municipal Health Planning Commission (ZY(2018-2020)-CCCX-2001-03), China; and Xinglin Young Scholar Program of Shanghai University of Traditional Chinese Medicine, China (A1-U17205010416); Postdoctoral Science Foundation of Jiangxi Province, China (2019KY42); Program of Jiangxi University of Traditional Chinese Medicine, China (2004/538200010402).
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Li, Z., Wu, F., Hong, Y. et al. The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating. AAPS PharmSciTech 21, 201 (2020). https://doi.org/10.1208/s12249-020-01739-4
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DOI: https://doi.org/10.1208/s12249-020-01739-4