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Biodegradable Ingredient-Based Emulgel Loaded with Ketoprofen Nanoparticles

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Abstract

Biodegradable materials are extensively employed to design nanocarriers that mimic extracellular environment in arthritis. The aim of this study was to formulate and characterize biocompatible, biodegradable ketoprofen-loaded chitosan-chondroitin sulfate (CHS-CS) nanoparticles with natural ingredients for transdermal applications. Polymers used in the design of nanocarriers are biodegradable and produce synergistic anti-inflammatory effect for the treatment of arthritis. For transdermal application, argan oil-based emulgel is utilized to impart viscosity to the formulation. Furthermore, naturally occurring argan oil synergizes anti-inflammatory effect of formulation and promotes skin penetration. CHS and CS form nanoparticles by polyelectrolyte complex formation or complex coacervation at pH 5.0. These particles were loaded into argan oil-based emulgel. Employing this method, nanoparticles were formulated with particle size in the range of 300–500 nm. These nanocarriers entrapped ketoprofen and showed more than 76% encapsulation efficiency and 77% release of the ketoprofen at pH 7.4 within 72 h. Drug releases from CHS-CS nanoparticles by mechanism of simple diffusion. Nanoparticle-loaded argan oil emulgel significantly enhanced skin penetration of ketoprofen as compared to marketed gel (p < 0.05). Nanocarriers prepared successfully delivered drug through transdermal route using natural ingredients.

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Authors and Affiliations

  1. Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    Rabia Gul, Naveed Ahmed, Naseem Ullah, Muhammad Ijaz Khan & Asim.ur. Rehman

  2. Department of Pharmacy, University of Swabi, Swabi, Pakistan

    Muhammad Ijaz Khan

  3. Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622, Lyon, France

    Abdelhamid Elaissari

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  1. Rabia Gul
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  2. Naveed Ahmed
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  3. Naseem Ullah
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Correspondence to Asim.ur. Rehman.

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Gul, R., Ahmed, N., Ullah, N. et al. Biodegradable Ingredient-Based Emulgel Loaded with Ketoprofen Nanoparticles. AAPS PharmSciTech 19, 1869–1881 (2018). https://doi.org/10.1208/s12249-018-0997-0

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