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Development of a New Method to Get a Reliable Powder Flow Characteristics Using Only 1 to 2 g of Powder

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Abstract

In powder technology, it is often important to directly measure real powder flow rate from a small amount of powder. For example, in pharmaceutical industry, a frequent problem is to determine powder flow properties of new active pharmaceutical ingredient (API) in an early stage of the development when the amount of API is limited. The purpose of this paper is to introduce a new direct method to measure powder flow when the material is poorly flowing (cohesive) and the amount of material is about 1 to 2 g. The measuring system was simple, consisting of a flow chamber and electronic balance and an automated optical detection system, and for each measurement, only 1 to 2 g of sample was required. Based on the results obtained with this testing method, three selected sugar excipients, three grades of microcrystalline cellulose, and APIs (caffeine, carbamazepine, and paracetamol) can be classified as freely flowing, intermediate flowing, and poorly flowing powders, respectively. The average relative standard deviation for the flow time determinations was not more than 2–10%. The present novel flowability testing method provides a new tool for a rapid determination of flowing characteristics of powders (e.g., inhalation powders) and granules at a small scale.

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Authors and Affiliations

  1. Orion Corporation, Espoo, Finland

    Kari Seppälä

  2. Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Viikinkaari 5E, Helsinki, Finland

    Jyrki Heinämäki, Juha Hatara, Lassi Seppälä & Jouko Yliruusi

Authors
  1. Kari Seppälä
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  2. Jyrki Heinämäki
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  3. Juha Hatara
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  4. Lassi Seppälä
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  5. Jouko Yliruusi
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Correspondence to Jyrki Heinämäki.

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Seppälä, K., Heinämäki, J., Hatara, J. et al. Development of a New Method to Get a Reliable Powder Flow Characteristics Using Only 1 to 2 g of Powder. AAPS PharmSciTech 11, 402–408 (2010). https://doi.org/10.1208/s12249-010-9397-9

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  • DOI: https://doi.org/10.1208/s12249-010-9397-9

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