Skip to main content
SpringerLink
Log in

Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory

  • Commentary
  • Landmark Publications in the Pharmaceutical Sciences: The Backstory
  • Published:
The AAPS Journal Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. Benet LZ, Ronfeld RA. Volume terms in pharmacokinetics. J Pharm Sci. 1969;58:639–41.

    Article  PubMed  CAS  Google Scholar 

  2. Benet LZ, Turi JS. Use of general partial fraction theorem for obtaining inverse Laplace transforms in pharmacokinetic analysis. J Pharm Sci. 1971;60:1593–4.

    Article  PubMed  CAS  Google Scholar 

  3. Rescigno A, Segre G. Drug and tracer kinetics. New York: Blaisdell; 1966.

    Google Scholar 

  4. Benet LZ. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. J Pharm Sci. 1972;61:536–41.

    Article  PubMed  CAS  Google Scholar 

  5. Bischoff KB, Dedrick RL, Zaharko DS. Preliminary model for methotrexate pharmacokinetics. J Pharm Sci. 1970;59:149–54.

    Article  PubMed  CAS  Google Scholar 

  6. Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1973;1:123–35.

    Article  PubMed  CAS  Google Scholar 

  7. Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn. 2010;37:529–39.

    Article  PubMed  CAS  Google Scholar 

  8. Wilkinson GR, Shand DG. Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther. 1975;18:377–90.

    PubMed  CAS  Google Scholar 

  9. Williams RL, Blaschke TF, Meffin PJ, Melmon KL, Rowland M. Influence of acute viral hepatitis on disposition and plasma protein binding. Clin Pharmacol Ther. 1977;21:301–9.

    PubMed  CAS  Google Scholar 

  10. Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. J Pharmacokinet Biopharm. 1978;6:153–64.

    Article  PubMed  CAS  Google Scholar 

  11. Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefamandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979;26:592–9.

    PubMed  CAS  Google Scholar 

  12. Oppenheimer JH, Schwartz HL, Surks MI. Determination of common parameters of iodothyronine metabolism and distribution in man by noncompartmental analysis. J Clin Endocrinol Metab. 1975;41:319–24.

    Article  PubMed  CAS  Google Scholar 

  13. Stewart GN. The pulmonary circulation time, the quantity of blood in the lungs, and the output of the heart. Am J Physiol. 1921;58:20–44.

    Google Scholar 

  14. Hamilton WF, Moore JW, Kinsman JM, Spurling RG. Studies on the circulation: IV. Further analysis of the injection method, and of changes in hemodynamics under physiological and pathological conditions. Am J Physiol. 1932;99:534–51.

    CAS  Google Scholar 

  15. Perl W, Samuel P. Input–output analysis for total input rate and total traced mass of body cholesterol in man. Circ Res. 1969;25:191–9.

    PubMed  CAS  Google Scholar 

  16. Oppenheimer JH, Schwartz HL, Surks MI. Erratum: Revised calculations of common parameters of iodothyronine metabolism and distribution by noncompartmental analysis. J Clin Endocrinol Metab. 1975;53:1172–3.

    Article  Google Scholar 

  17. Benet LZ, Galeazzi RL. Noncompartmental determination of the volume of distribution steady-state. J Pharm Sci. 1979;68:1071–4.

    Article  PubMed  CAS  Google Scholar 

  18. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm. 1978;6:547–58.

    Article  PubMed  CAS  Google Scholar 

  19. Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharm Res. 2008;25:2869–77.

    Article  PubMed  CAS  Google Scholar 

  20. Grover A, Benet LZ. Intermittent drug dosing intervals by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. J Pharmacokinet Pharmacodyn. 2011;38:369–83.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, 94143, USA

    Leslie Z. Benet

Authors
  1. Leslie Z. Benet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Leslie Z. Benet.

Additional information

Editor: Ho-Leung Fung

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benet, L.Z. Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory. AAPS J 14, 164–167 (2012). https://doi.org/10.1208/s12248-012-9326-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1208/s12248-012-9326-9

KEY WORDS

Search

Navigation