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Pharmacokinetics of cefamandole using a HPLC assay

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Abstract

A pharmacokinetic study was carried out on six normal healthy adults with average creatinine clearances ranging from 94.8 to 129.3 ml/min. Cefamandole, 15 mg/kg, was administered intravenously over a period of 10 min. Frequent and prolonged samplings of blood and urine were made. Specimens were assayed by a sensitive, accurate, and reproducible HPLC assay. An excellent computer fit to a threecompartment body model was observed. T1/2 α, β, and γ were 5.1, 23.6, and 74.2 min, respectively. The relatively long terminal T1/2 and the area under the curve (AUC) contributed by the γ phase being 31% suggest that a multicompartmental kinetic nature of cefamandole cannot be ignored. Volume of distribution (VDSS)averaged 11.8 liters, and the serum clearance was 200 ml/min. Ninetysix percent was excreted in the urine, and therefore a very high urinary concentration was achieved. The concentration in the plasma exceeds the MIC of many grampositive and negative organisms for many hours.

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Author notes

  1. Nik S. Aziz

    Present address: Department of Pharmacology, School of Medicine, University of California, 95616, Davis, California

Authors and Affiliations

  1. Division of Clinical Pharmacology, Department of Medicine, School of Medicine, University of California, 94143, San Francisco, California

    Nik S. Aziz

  2. Division of Clinical Pharmacy, School of Pharmacy, University of California, 94143, San Francisco, California

    John G. Gambertoglio

  3. Department of Pharmacy, School of Pharmacy, University of California, 94143, San Francisco, California

    Emil T. Lin & Leslie Z. Benet

  4. Department of Medicine, School of Medicine, University of California, 94143, San Francisco, California

    Henry Grausz

Authors
  1. Nik S. Aziz
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  2. John G. Gambertoglio
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  3. Emil T. Lin
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  4. Henry Grausz
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  5. Leslie Z. Benet
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Additional information

This investigation was supported in part by a grant from Lilly Research Laboratories. During the course of this work, Dr. Aziz received support as a Postdoctoral Research Fellow in Clinical Pharmacology from Universiti Kebangsaan Malaysia.

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Aziz, N.S., Gambertoglio, J.G., Lin, E.T. et al. Pharmacokinetics of cefamandole using a HPLC assay. Journal of Pharmacokinetics and Biopharmaceutics 6, 153–164 (1978). https://doi.org/10.1007/BF01117449

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  • DOI: https://doi.org/10.1007/BF01117449

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