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Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

  • Research Article
  • Theme: Advances in PAT, QbD, and Material Characterization
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A Correction to this article was published on 26 June 2019

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Abstract

The use of inkjet printing for pharmaceutical manufacturing is gaining interest for production of personalized dosage forms tailored to specific patients. As part of the manufacturing, it is imperative to ensure that the correct dose is printed. The aim of this study was to use inkjet printing for manufacturing of personalized dosage forms combined with the use of near-infrared (NIR) and Raman spectroscopy as complementary analytical techniques for active pharmaceutical ingredient (API) quantification of the inkjet-printed dosage forms. Three APIs, propranolol (0.5–4.1 mg), montelukast (2.1–12.1 mg), and haloperidol (0.6–4.1 mg) were inkjet printed in 1 cm2 areas on a porous substrate. The printed doses were non-destructively analyzed by transmission NIR and Raman spectroscopy (both transmission and backscatter). X-ray computed microtomography (μ-CT) analysis was undertaken for porosity measurements of the substrate. The API content was confirmed using high-performance liquid chromatography (HPLC), and the content in the dosage forms was modeled from the NIR and Raman spectra using partial least squares regression (PLS). HPLC analysis revealed a linear correlation of the number of layers printed to the API content. The resulting PLS models for both NIR and Raman had R2 values between 0.95 and 0.99. The best predictive model was obtained using NIR, followed by Raman spectroscopy. μ-CT revealed the substrate to be highly porous and optimal for inkjet printing. In conclusion, NIR and Raman spectroscopic techniques could be used complementary as fast API quantification tools for inkjet-printed medicines.

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Change history

  • 26 June 2019

    Mohammed Al-Sharabi’s affiliation was incorrect at the time of publishing. The updated affiliation appears below.

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Funding

The results presented in this work was supported by The Danish Council for Independent Research (DFF), Technology and Production Sciences (FTP), grant number 12-126515/0602-02670B and the Drug Research Academy (University of Copenhagen).

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark

    Magnus Edinger, Laura-Diana Iftimi, Daniel Bar-Shalom, Jukka Rantanen & Natalja Genina

  2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

    Daniel Markl & Mohammed Al-Sharabi

  3. EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Strathclyde, Glasgow, UK

    Daniel Markl

Authors
  1. Magnus Edinger
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  2. Laura-Diana Iftimi
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  3. Daniel Markl
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  4. Mohammed Al-Sharabi
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  5. Daniel Bar-Shalom
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  6. Jukka Rantanen
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  7. Natalja Genina
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Corresponding author

Correspondence to Natalja Genina.

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Guest Editors: William C. Stagner and Rahul V. Haware

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Edinger, M., Iftimi, LD., Markl, D. et al. Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy. AAPS PharmSciTech 20, 207 (2019). https://doi.org/10.1208/s12249-019-1423-y

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