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Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents

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Abstract

Three-layer thin films comprising of two polymers as substrate (ethyl cellulose and, copovidone K28) and three antihypertensive agents (hydrochlorothiazide, amiloride HCl, and carvedilol) were printed using jet dispensing technology. Two film formulations with different ethyl cellulose to copovidone K28 ratio (i.e., 90/10 and 50/50 w/w) were prepared using a three-course dispensing. The films were characterized regarding surface morphology, solid-state properties, polymer-drug interactions, drug distribution in each layer, and in vitro drug release. All the components of the films were found to be in the amorphous state apart from hydrochlorothiazide which retained its crystallinity. FT-IR spectroscopy revealed hydrogen bond interactions between carvedilol and copovidone K28. Combinations of ethyl cellulose and copovidone K28 provide suitable polymeric film substrates with the ability to modify drug release. Particularly, decreased ethyl cellulose to copovidone K28 weight ratio was found to suppress the crystallization of hydrochlorothiazide and to increase the release rate of the dispensed drugs. Jet dispensing was found to be a rapid technology for the preparation of multi-layered films that can be used as personalized formulations for the delivery of combinations of drugs.

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Acknowledgements

The authors are grateful to Ms. Devyani Amin (University of Greenwich) for her help with the development of the HPLC method.

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Authors and Affiliations

  1. Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent, ME4 4TB, UK

    Nicolaos Scoutaris, Maria Malamatari, Adrien Letellier & Dennis Douroumis

  2. University of Rouen, 76130, Mont-Saint-Aignan, France

    Adrien Letellier

Authors
  1. Nicolaos Scoutaris
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  2. Maria Malamatari
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  3. Adrien Letellier
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  4. Dennis Douroumis
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Correspondence to Dennis Douroumis.

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Scoutaris, N., Malamatari, M., Letellier, A. et al. Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents. Drug Deliv. and Transl. Res. 8, 32–42 (2018). https://doi.org/10.1007/s13346-017-0430-3

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  • DOI: https://doi.org/10.1007/s13346-017-0430-3

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