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Process Investigation of a Novel Compaction Technique With Pellet-Containing Granules

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Abstract

Objective

The purpose of this study was to investigate the influence of the preparing process on the properties of pellet-containing granules and tablets.

Methods

Coated pellets were granulated by centrifugal granulation, and the obtained pellet-containing granules were mixed with cushioning granules and compressed into tablets. Tablets were characterized for a drug release rate as compared with the original coated pellets.

Results

The surface roughness and the angle of repose of pellet-containing granules increased with the granulating ratio. Weight and drug content variations in tablets were diminished by granulation, and great improvement in tablet uniformity was achieved even for large pellets. Granulation showed protection for coated films under different compress forces and at even a low content of cushioning granules.

Conclusions

The uniformity of tablets prepared from pellet-containing granules could be significantly improved by the granulation process at a proper granulating ratio. The granulation process could protect the coated pellets during compaction even under high compression forces and with a low content of cushioning granules.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China

    Xin Pan PhD, Ying Huang, Yixuan Dong, Zhouhua Wang, Chune Zhu, Bao Chen PhD & Chuanbin Wu PhD

  2. Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China

    Ge Li & Chuanbin Wu PhD

Authors
  1. Xin Pan PhD
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  2. Ying Huang
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  3. Yixuan Dong
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  4. Zhouhua Wang
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  5. Chune Zhu
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  6. Ge Li
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  7. Bao Chen PhD
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  8. Chuanbin Wu PhD
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Corresponding author

Correspondence to Chuanbin Wu PhD.

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Pan, X., Huang, Y., Dong, Y. et al. Process Investigation of a Novel Compaction Technique With Pellet-Containing Granules. Ther Innov Regul Sci 47, 593–601 (2013). https://doi.org/10.1177/2168479013495681

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  • DOI: https://doi.org/10.1177/2168479013495681

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