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Theoretical study of a membrane channel gated by ATP

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Abstract

We study channel transport across biomembranes. We propose a model that couples the diffusive dynamics with the gating process via a two-state ratchet mechanism. This gating process is governed by ATP binding and hydrolysis, and the process exhibits Michaelis-Menten enzymatic kinetics. The particle flow and permeability of the channel are studied both analytically and numerically in the steady-state regime, while working between fixed concentrations. The results are compared with simpler models and with experimental data. Also, a simulation framework, that allows high flexibility in parameter exploration, is introduced.

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Authors and Affiliations

  1. Departament d’Estructura i Constituents de la Matèria, Universitat de Barcelona, Martí i Franquès 1, E-08028, Barcelona, Spain

    J. G. Orlandi & J. M. Sancho

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  1. J. G. Orlandi
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  2. J. M. Sancho
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Correspondence to J. G. Orlandi.

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Orlandi, J.G., Sancho, J.M. Theoretical study of a membrane channel gated by ATP. Eur. Phys. J. E 29, 329–336 (2009). https://doi.org/10.1140/epje/i2009-10483-9

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  • DOI: https://doi.org/10.1140/epje/i2009-10483-9

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