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Dynamics of intramolecular recognition: Base-pairing in DNA/RNA near and far from equilibrium

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Abstract.

The physics of the base-pairing interaction in DNA and RNA molecules plays a fundamental role in biology. Past experimental and theoretical research has led to a fairly complete and quantitative understanding of the equilibrium properties such as the different phases, the melting behavior, and the response to slow stretching. The non-equilibrium behavior is even richer than might be expected on the basis of thermodynamics. However, the non-equilibrium behavior is also far less understood. Here, we review different theoretical approaches to the study of base-pairing thermodynamics and kinetics, and illustrate the rich phenomenology with several examples that use these approaches.

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Authors and Affiliations

  1. Department of Physics, The Ohio State University, 43210-1117, Columbus, OH, USA

    R. Bundschuh

  2. Arnold-Sommerfeld Center for Theoretical Physics and Center for Nanoscience (CeNS), LMU München, Theresienstrasse 37, 80333, München, Germany

    U. Gerland

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  1. R. Bundschuh
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  2. U. Gerland
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Bundschuh , R., Gerland, U. Dynamics of intramolecular recognition: Base-pairing in DNA/RNA near and far from equilibrium. Eur. Phys. J. E 19, 319–329 (2006). https://doi.org/10.1140/epje/i2005-10061-3

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