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Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae

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Russian Journal of Genetics: Applied Research

Abstract

Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

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Authors and Affiliations

  1. Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia

    Yu. V. Andreychuk, A. A. Shiryaeva, A. S. Zhuk, E. I. Stepchenkova & S. G. Inge-Vechtomov

  2. Vavilov Institute of General Genetics, St. Petersburg Branch, Russian Academy of Sciences, St. Petersburg, Russia

    A. S. Zhuk, E. I. Stepchenkova & S. G. Inge-Vechtomov

Authors
  1. Yu. V. Andreychuk
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  2. A. A. Shiryaeva
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  3. A. S. Zhuk
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  4. E. I. Stepchenkova
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  5. S. G. Inge-Vechtomov
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Corresponding author

Correspondence to Yu. V. Andreychuk.

Additional information

Original Russian Text © Yu.V. Andreychuk, A.A. Shiryaeva, A.S. Zhuk, E.I. Stepchenkova, S.G. Inge-Vechtomov, 2015, published in Ecologicheskaya Genetika, 2015, Vol. 13, No. 4, pp. 22–24.

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Andreychuk, Y.V., Shiryaeva, A.A., Zhuk, A.S. et al. Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae . Russ J Genet Appl Res 7, 172–174 (2017). https://doi.org/10.1134/S2079059717020022

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  • DOI: https://doi.org/10.1134/S2079059717020022

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