Skip to main content
SpringerLink
Log in

Recessive mutations in SUP35 and SUP45 genes coding for translation release factors affect chromosome stability in Saccharomyces cerevisiae

  • ORIGINAL PAPER
  • Published:
Current Genetics Aims and scope Submit manuscript

Abstract

Chromosome stability in suppressor mutants for SUP35 and SUP45 genes coding for translation release factors was studied. We obtained spontaneous and UV-induced sup35 or sup45 mutants in a haploid strain disomic for chromosome III and tested the stability of an extra copy of this chromosome. The majority of the mutants showed increased chromosome instability. This phenotype was correlated with an increased sensitivity to the microtubule-poisoning drug benomyl which affects chromosome segregation at anaphase. Our data suggest that termination-translation factors eRF3 and eRF1 control chromosome transmission at mitotic anaphase in Saccharomyces cerevisiae.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Genetics and Breeding, Saint-Petersburg State University, University Emb. 7/9, 199034, Saint-Petersburg, Russia e-mail: borch@paloma.spbu.ru, aborchsenius@hotmail.com Tel.: +812 428-65-70; Fax: +812 428-77-33, , , , , , RU

    Andrey S. Borchsenius, Anna A. Tchourikova & Sergey G. Inge-Vechtomov

Authors
  1. Andrey S. Borchsenius
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna A. Tchourikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sergey G. Inge-Vechtomov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 26 July 1999 / 27 January 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borchsenius, A., Tchourikova, A. & Inge-Vechtomov, S. Recessive mutations in SUP35 and SUP45 genes coding for translation release factors affect chromosome stability in Saccharomyces cerevisiae. Curr Genet 37, 285–291 (2000). https://doi.org/10.1007/s002940050529

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002940050529

Search

Navigation