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Epigenetical mechanisms of susceptibility to complex human diseases

  • Published:
Russian Journal of Genetics: Applied Research

Abstract

Contemporary data concerning the input of epigenetical mechanisms into etiology and the susceptibility to complex human diseases are analyzed critically. Special attention was paid to the specific role of simple tandem DNA repeats and the crucial role of developmental epigenetics in these processes. In particular patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

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  1. Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, Saint Petersburg, 197376, Russia

    E. L. Patkin

  2. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

    J. Quinn

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Original Russian Text © E.L. Patkin, J. Quinn, 2010, published in Ekologicheskaya Genetika, 2010, Vol. 8, No. 4, pp. 44–56.

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Patkin, E.L., Quinn, J. Epigenetical mechanisms of susceptibility to complex human diseases. Russ J Genet Appl Res 1, 436–447 (2011). https://doi.org/10.1134/S2079059711050121

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