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Cytogenetic anomalies in the mucosa of the fundic region of the stomach in patients with chronic gastritis

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Russian Journal of Genetics: Applied Research

Abstract

The stomach is one of the human body’s microecological systems. A special role in the gastric ecosystem belongs to Helicobacter pylori (HP). Patients of different age groups with chronic gastritis, both HP-infected and noninfected, were cytogenetically investigated using a method based on micronuclei (MN) count in the mucocytes of the fundus. Some morphological changes in the nuclei, such as protrusion, presence of two nuclei in mucocytes, and parietal cells, were found. A significant increase in the count of cells with MN was found in HP-positive patients, compared to the noninfected subjects from all age groups. The investigations have revealed changes in the share of parietal cells with two nuclei in patients with PH-associated gastritis.

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Authors and Affiliations

  1. Mechnikov State Medical Academy, Mechnikov, Russia

    L. V. Kitaeva

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  1. L. V. Kitaeva
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Correspondence to L. V. Kitaeva.

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Original Russian Text © L.V. Kitaeva, 2010, published in Ekologicheskaya Genetika, 2010, Vol. 8, No. 1, pp. 36–41.

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Kitaeva, L.V. Cytogenetic anomalies in the mucosa of the fundic region of the stomach in patients with chronic gastritis. Russ J Genet Appl Res 1, 396–401 (2011). https://doi.org/10.1134/S2079059711050091

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  • DOI: https://doi.org/10.1134/S2079059711050091

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