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Risk allele frequencies of several genes controlling the development of autoimmune pathologies in the population of belarus

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Russian Journal of Genetics: Applied Research

Abstract

The population genotype and allele frequencies of +49A/G of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4); −1858C/T of the protein tyrosine phosphatase gene (PTPN22); and −23HphIA/T of the insulin gene (INS) were detected in ethnic Belarusians from six ethnogeographical regions. Frequencies of the risk allele homozygous carriers were 17.3% for the CTLA4 gene +49G, 50.7% for the insulin gene −23HphIA, and 4.1 for the PTPN22 gene −1858T. The homozygous risk genotype of all three loci was detected in five individuals of 662 individuals tested; the homozygous combination of protective alleles was detected in 21 individuals. The similarity in the allele and genotype distribution of the studied loci on the territory of Belarus was demonstrated.

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Authors and Affiliations

  1. Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, Russia

    E. A. Aksyonova, T. N. Pokladok, D. V. Boiko & N. G. Danilenko

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  1. E. A. Aksyonova
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  2. T. N. Pokladok
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  3. D. V. Boiko
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  4. N. G. Danilenko
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Correspondence to E. A. Aksyonova.

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Original Russian Text © E.A. Aksyonova, T.N. Pokladok, D.V. Boiko, N.G. Danilenko, 2010, published in Ekologicheskaya Genetika, 2010, Vol. 8, No. 1, pp. 50–58.

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Aksyonova, E.A., Pokladok, T.N., Boiko, D.V. et al. Risk allele frequencies of several genes controlling the development of autoimmune pathologies in the population of belarus. Russ J Genet Appl Res 1, 402–410 (2011). https://doi.org/10.1134/S2079059711050029

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  • DOI: https://doi.org/10.1134/S2079059711050029

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