Abstract
Comparative studies on the genotoxic activity of cisplatin and morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A—methylmorpholine), have been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited biphasic dose-effect relationship: a linear decrease of the DNA percent in the comet tail and a plateau region. However, in the plateau region, morfozol caused a 6-fold reduction of the DNA percent in the comet tail while cisplatin caused a 2-fold decrease only. Morfozol, like cisplatin, inducing DNA-protein cross-linking and generating reactive oxygen species, was more effective than cisplatin.
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Original Russian Text © A.K. Grekhova, L.B. Gorbacheva, N.A. Ivanova, I.A. Efimenko, A.N. Osipov, 2013, published in Biomeditsinskaya Khimiya.
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Grekhova, A.K., Gorbacheva, L.B., Ivanova, N.A. et al. Comparative studies of the genotoxic activity of a new palladium (II) acidocomplex and cisplatin in human blood lymphocytes in vitro. Biochem. Moscow Suppl. Ser. B 7, 226–230 (2013). https://doi.org/10.1134/S1990750813030050
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DOI: https://doi.org/10.1134/S1990750813030050