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The Statue of Cytokines Therapy in Blood Transfusion Running Cytokine and Blood Transfusion

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Abstract

In order to improve the patient’s condition, the transfusion of blood products is used, however, there are problems with blood transfusion including infections, immune suppression, allergic reactions and anaphylactic shock-related to leukemia and plasma product. Cytokine can now be an appropriate choice to reduce the need for blood transfusion. Various types of cytokines have been studied in human clinical trials and some of them have a substantial function to decrease blood transfusion. In this study, we have investigated the important cytokines involved in reducing cells (Red blood cells and platelets) transfusion. First, we have investigated the cytokines involved in erythropoiesis and thrombopoiesis and covered some clinical studies about them. The second side effects of the administration of these cytokines have been addressed, and finally, we have suggested some recommendations about cytokine therapy.

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ACKNOWLEDGMENTS

We would like to thank all our colleagues in the Department of Laboratory Sciences in Kermanshah University of Medical Sciences for assistance with the manuscript.

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Authors and Affiliations

  1. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Ali Maleki

  2. Department of Medical Laboratory Science, School of paramedical, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Fatemeh Sayyadipour & Fakhredin Saba

  3. Department of anatomy. Medical school, Tehran University of Medical School, Tehran, Iran

    Hamid Ahmadi

  4. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Masoud Soleimani

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  1. Ali Maleki
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  2. Fatemeh Sayyadipour
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  3. Hamid Ahmadi
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  4. Masoud Soleimani
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  5. Fakhredin Saba
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Correspondence to Fakhredin Saba.

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Ali Maleki, Sayyadipour, F., Ahmadi, H. et al. The Statue of Cytokines Therapy in Blood Transfusion Running Cytokine and Blood Transfusion. Cell Tiss. Biol. 13, 407–417 (2019). https://doi.org/10.1134/S1990519X19060051

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  • DOI: https://doi.org/10.1134/S1990519X19060051

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