Skip to main content
SpringerLink
Log in

Polycarbonate-Based Nanoparticles with Aggregation-Induced Emission (AIE): Synthesis and Application for Cell Imaging

  • SYNTHESIS
  • Published:
Polymer Science, Series B Aims and scope Submit manuscript

Abstract

The fluorescent nanoparticles with aggregation-induced emission have caused tremendous research interest. In this work, the polycarbonates-based fluorescent nanoparticles with aggregation-induced emission (AIE) have been prepared by a facile and efficient approach of ring-opening polymerization and click chemistry. The tetraphenylethylene moieties that feature the AIE characteristics can be facilely grafted onto the polymer main chain by click reaction between azide-terminated tetraphenylethene derivative and alkyne-bearing amphiphilic block copolymer poly(ethylene glycol)-block-poly(5-methyl-5-propargylxycarbonyl-1,3-dioxane-2-one). The resulted tetraphenylethylene substituted block copolymers possess amphiphilic properties and are able to self-assemble into fluorescent polymeric nanoparticles. Based on cellular imaging experiments, we demonstrated that these fluorescent nanoparticles have great potential for cells imaging applications due to their attractive properties including strong fluorescence intensity, great water dispersibility, excellent biocompatibility and high cellular uptake efficiency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1.
Scheme 2.
Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. O. S. Wolfbeis, Chem. Soc. Rev. 44, 4743 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. A. Reisch and A. S. Klymchenko, Small 12, 1968 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. H. S. Peng and D. T. Chiu, Chem. Soc. Rev. 44, 4699 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. L. L. Yan, Y. Zhang, B. Xu, and W. J. Tian, Nanoscale 8, 2471 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. P. D. Howes, R. Chandrawati, and M. M. Stevens, Science 346, 1247390 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. J. Zhang, R. Chen, Z. Zhu, C. Adachi, X. Zhang, and C. S. Lee, ACS Appl. Mater. Interfaces 7, 26266 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. I. Fischer, K. Petkau-Milroy, Y. L. Dorland, A. P. H. J. Schenning, and P. L. Brunsveld, Chem. - Eur. J. 19, 16646 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. F. Tang, C. Wang, J. Wang, X. Wang, and L. Li, ACS Appl. Mater. Interfaces 6, 18337 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. F. F. An, J. Ye, J. F. Zhang, Y. L. Yang, C. J. Zheng, X. J. Zhang, Z. Liu, C. S. Lee, and X. H. Zhang, J. Mater. Chem. B 1, 3144 (2013).

    Article  CAS  Google Scholar 

  10. C. Ma, X. Zhang, K. Wang, X. Zhang, Y. Zhou, H. Liu, and Y. Wei, Polym. Chem. 6, 3634 (2015).

    Article  CAS  Google Scholar 

  11. J. Luo, Z. Xie, J. W. Y. Lam, L. Cheng, H. Chen, C. Qiu, H. S. Kwok, X. Zhan, Y. Liu, D. Zhu, and B. Tang, Chem. Commun. 18, 1740 (2001).

    Article  Google Scholar 

  12. J. Mei, Y. Hong, J. W. Lam, A. Qin, Y. Tang, and B. Z. Tang, Adv. Mater. 26, 5429 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. J. Mei, N. L. Leung, R. T. Kwok, J. W. Lam, and B. Z. Tang, Chem. Rev. 115, 11718 (2015).

    Article  CAS  PubMed  Google Scholar 

  14. X. Zhang, K. Wang, M. Liu, X. Zhang, L. Tao, Y. Chen, and Y. Wei, Nanoscale 7, 11486 (2015).

    Article  CAS  PubMed  Google Scholar 

  15. R. Zhan, Y. Pan, P. N. Manghnani, and B. Liu, Macromol. Biosci. 17, 1600433 (2017).

    Article  CAS  Google Scholar 

  16. Z. Cao, X. Liang, H. Chen, M. Gao, Z. Zhao, X. Chen, G. Qu, D. Qi, and B. Z. Tang, Polym. Chem. 7, 5571 (2016).

    Article  CAS  Google Scholar 

  17. C. Li, X. Liu, S. He, Y. Huang, and D. Cui, Polym. Chem. 7, 1121 (2016).

    Article  CAS  Google Scholar 

  18. X. Zhang, L. Tao, Z. Chi, J. Xu, and Y. Wei, J. Mater. Chem. B 2, 4398 (2014).

    Article  CAS  Google Scholar 

  19. F. Hu, Y. Yuan, W. Wu, D. Mao, and B. Liu, Anal. Chem. 90, 6718 (2018).

    Article  CAS  PubMed  Google Scholar 

  20. H. Huang, M. Liu, S. Luo, K. Wang, Q. Wan, F. Deng, D. Xu, X. Zhang, and Y. Wei, Chem. - Eng. J. 304, 149 (2016).

    Article  CAS  Google Scholar 

  21. Q. Wan, C. He, K. Wang, M. Liu, H. Huang, Q. Huang, F. Deng, X. Zhang, and Y. Wei, Tetrahedron 71, 8791 (2015).

    Article  CAS  Google Scholar 

  22. Q. Wan, K. Wang, H. Du, H. Huang, M. Liu, F. Deng, Y. Dai, X. Zhang, and Y. Wei, Polym. Chem. 6, 5288 (2015).

    Article  CAS  Google Scholar 

  23. Q. Wan, K. Wang, C. He, M. Liu, G. Zeng, H. Huang, F. Deng, X. Zhang, and Y. Wei, Polym. Chem. 6, 8214 (2015).

    Article  CAS  Google Scholar 

  24. J. Qian and B. Z. Tang, Chem 3, 56 (2017).

    Article  CAS  Google Scholar 

  25. S. Chen, Q. Chen, Q. Li, J. An, P. Sun, J. Ma, and H. Gao, Chem. Mater. 30, 1782 (2018).

    Article  CAS  Google Scholar 

  26. G. Feng, J. Liu, C.J. Zhang, and B. Liu, ACS Appl. Mater. Interfaces 10, 11546 (2018).

    Article  CAS  PubMed  Google Scholar 

  27. W. Zhuang, Y. Xu, G. Li, J. Hu, B. Ma, T. Yu, X. Su, and Y. Wang, ACS Appl. Mater. Interfaces 10, 18489 (2018).

    Article  CAS  PubMed  Google Scholar 

  28. H. Han, Q. Jin, H. Wang, W. Teng, J. Wu, H. Tong, T. Chen, and J. Ji, Small 12, 3870 (2016).

    Article  CAS  PubMed  Google Scholar 

  29. S. S. Liow, H. Zhou, S. Sugiarto, S. Guo, M. L. S. Chalasani, N. K. Verma, J. Xu, and X. J. Loh, Biomacromolecules 18, 886 (2017).

    Article  CAS  PubMed  Google Scholar 

  30. Q. Zhang, C. Shen, N. Zhao, and F. Xu, Adv. Funct. Mater. 27, 1606229 (2017).

    Article  CAS  Google Scholar 

  31. M. N. Ganivada, P. Kumar, P. Kanjilal, H. Dinda, J. D. Sarma, and R. Shunmugam, Polym. Chem. 7, 4237 (2016).

    Article  CAS  Google Scholar 

  32. S. Tempelaar, L. Mespouille, O. Coulembier, P. Dubois, and A. P. Dove, Chem. Soc. Rev. 42, 1312 (2013).

    Article  CAS  PubMed  Google Scholar 

  33. F. R. Cheng, T. Su, J. Cao, X. L. Luo, L. Li, Y. Pu, and B. He, J. Mater. Chem. B 6, 2258 (2018).

    Article  CAS  Google Scholar 

  34. Q. Shi, X. Chen, T. Lu, and X. Jing, Biomaterials 29, 1118 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

ACKNOWLEDGMENTS

This work was supported by Jiangsu Key Laboratory of Fine Petrochemical Engineering, Changzhou University (KF1704).

Author information

Authors and Affiliations

  1. School of Chemistry and Biology, Yancheng Institute of Technology, 224051, Yancheng, China

    Huaihong Zhang, Tao Zhou, Qing Yu, Zhaosheng Cai & Hui Cang

  2. College of Chemistry and Chemical Engineering, Southeast University, 211189, Nanjing, China

    Huaihong Zhang

  3. School of Materials and Chemistry, West Anhui University, 237010, Lu’an, China

    Ziqun Huang

Authors
  1. Huaihong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ziqun Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tao Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qing Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhaosheng Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hui Cang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Huaihong Zhang or Hui Cang.

Additional information

The article is published in the original.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huaihong Zhang, Huang, Z., Zhou, T. et al. Polycarbonate-Based Nanoparticles with Aggregation-Induced Emission (AIE): Synthesis and Application for Cell Imaging. Polym. Sci. Ser. B 61, 266–274 (2019). https://doi.org/10.1134/S1560090419030187

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1560090419030187

Search

Navigation